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215112

Phosphorous acid

99%

Synonym(s):

Phosphonic acid

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About This Item

Empirical Formula (Hill Notation):
H3O3P
CAS Number:
13598-36-2
Molecular Weight:
82.00
NACRES:
NA.21
PubChem Substance ID:
329752161
UNSPSC Code:
12352106
EC Number:
237-066-7
MDL number:
MFCD00137258
Assay:
99%
Form:
crystals or chunks, flakes

Key Documents

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InChI key

ABLZXFCXXLZCGV-UHFFFAOYSA-N

InChI

1S/H3O3P/c1-4(2)3/h4H,(H2,1,2,3)

SMILES string

[H]P(O)(O)=O

assay

99%

form

crystals or chunks, flakes

Quality Level

100

pH

(acidic)

solubility

water: soluble

density

1.651 g/mL at 25 °C (lit.)

Related Categories

General description

Phosphorous acid (or phosphonic acid) is a phosphorus oxoacid commonly used as an intermediate in chemical synthesis for the production of various phosphorus compounds. It is also used as a strong reducing agent in organic synthesis.

Application

Phosphorous acid (H3PO3, orthophosphorous acid) may be used as one of the reaction components for the synthesis of the following:
  • α-aminomethylphosphonic acids via Mannich-Type Multicomponent Reaction
  • 1-aminoalkanephosphonic acids via amidoalkylation followed by hydrolysis
  • N-protected α-aminophosphonic acids (phospho-isosteres of natural amino acids) via amidoalkylation reaction

pictograms

CorrosionExclamation mark
GHS05,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Met. Corr. 1 - Skin Corr. 1A

Storage Class

8A - Combustible corrosive hazardous materials

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

危险化学品
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Certificates of Analysis (COA)

Lot/Batch Number
MKDB0919
MKCZ6678
MKCS2013
MKCS4814
MKCP8300

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

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    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What is Product 215112, Phosphorous acid, soluble in?

    Phosphorous acid is appreciably soluble in water.

  6. What is the melting point of Product 215112, Phosphorous acid?

    The melting point of phosphorous acid is approximately 74°C.

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    Ask a Scientist here.

Amidoalkylation of phosphorous acid.
Vinyukov AV, et al.
Russ. J. Gen. Chem., 85(2), 366-369 (2015)
Marina Borges Osorio et al.
Plant physiology, 181(1), 332-352 (2019-07-03)
Phosphorus (P) is an essential macronutrient for all living organisms and limits plant growth. Four proteins comprising a single SYG1/Pho81/XPR1 (SPX) domain, SPX1 to SPX4, are putative phosphate-dependent inhibitors of Arabidopsis (Arabidopsis thaliana) PHOSPHATE STARVATION RESPONSE1 (PHR1), the master transcriptional
Amidoalkylation of phosphorous acid.
Oleksyszyn J and Gruszeckae.
Tetsu to Hagane, 22(36), 3537-3540 (1981)
Yunjun Guo et al.
Bioconjugate chemistry, 23(7), 1470-1477 (2012-06-06)
Somatostatin receptors (SSTr) are overexpressed in a wide range of neuroendocrine tumors, making them excellent targets for nuclear imaging and therapy, and radiolabeled somatostatin analogues have been investigated for positron emission tomography imaging and radionuclide therapy of SSTr-positive tumors, especially
Abraham Vega et al.
Langmuir : the ACS journal of surfaces and colloids, 28(21), 8046-8051 (2012-05-05)
Phosphonic acid monolayers are being considered as versatile surface modification agents due to their unique ability to attach to surfaces in different configurations, including mono-, bi-, or even tridentate arrangements. Tethering by aggregation and growth (T-BAG) of octadecylphosphonic acid (ODPA)
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