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Merck
CN

21218

Calcium phosphate

purum p.a., ≥96.0% (calc. as Ca3(PO4)2, KT)

Synonym(s):

β-Calcium phosphate tribasic, β-Tricalcium phosphate, tert-Calcium phosphate, tri-Calcium (ortho)phosphate

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About This Item

Empirical Formula (Hill Notation):
Ca3O8P2
CAS Number:
7758-87-4
Molecular Weight:
310.18
NACRES:
NA.21
PubChem Substance ID:
329752121
UNSPSC Code:
12352300
EC Number:
231-840-8
MDL number:
MFCD00015984

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Product Name

Calcium phosphate, purum p.a., ≥96.0% (calc. as Ca3(PO4)2, KT)

InChI key

QORWJWZARLRLPR-UHFFFAOYSA-H

InChI

1S/3Ca.2H3O4P/c;;;2*1-5(2,3)4/h;;;2*(H3,1,2,3,4)/q3*+2;;/p-6

SMILES string

[Ca++].[Ca++].[Ca++].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O

grade

purum p.a.

assay

≥96.0% (calc. as Ca3(PO4)2, KT)

form

powder

loss

≤0.1% loss on ignition, 800 °C

anion traces

chloride (Cl-): ≤500 mg/kg
sulfate (SO42-): ≤1000 mg/kg

cation traces

Cd: ≤50 mg/kg
Co: ≤50 mg/kg
Cu: ≤50 mg/kg
Fe: ≤200 mg/kg
K: ≤500 mg/kg
Na: ≤1000 mg/kg
Ni: ≤50 mg/kg
Pb: ≤50 mg/kg
Zn: ≤50 mg/kg

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General description

Calcium phosphate (tri calcium phosphate) is a colorless amorphous solid. Its pure form can be obtained by melting CaO with phosphorus (V) oxide at 1100°C. It is used as polish in toothpastes and also in making enamels and opaque glasses.
Calcium phosphate occurs naturally as the minerals: oxydapatit, voelicherite and whitlockite. It is mainly used for developing osteoconductive biomaterials for use as bone substitutes.

Application

Composite of calcium phosphate and a bioactive glass may be employed for the manufacture of customized implants, via 3D-printing process. Dense and homogeneous calcium phosphate coatings may be used for coating the metal implants.

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCCG4331
BCCD6142
BCCC6948
BCCB1918
BCBX7541

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Calcium phosphate-based osteoinductive materials.
LeGeros RZ.
Chemical Reviews, 108(11), 4742-4753 (2008)
S Leeuwenburgh et al.
Journal of biomedical materials research, 56(2), 208-215 (2001-05-08)
A new biomimetic method for coating metal implants enables the fast formation of dense and homogeneous calcium phosphate coatings. Titanium alloy (Ti6Al4V) disks were coated with a thin, carbonated, amorphous calcium phosphate (ACP) by immersion in a saturated solution of
Calcium phosphates compounds in conjunction with hydrogel as carrier for BMP-2: a study on ectopic bone formation in rats.
Hulsart-Billstrom G, et al.
Acta Biomaterialia, 7(8), 3042-3049 (2011)
3D printing of bone substitute implants using calcium phosphate and bioactive glasses.
Bergmann C, et al.
J. Eur. Ceram. Soc., 30(12), 2563-2563 (2010)
Françoise Borcard et al.
Journal of medicinal chemistry, 55(18), 7988-7997 (2012-08-18)
To control the selective adhesion of human endothelial cells and human serum proteins to bioceramics of different compositions, a multifunctional ligand containing a cyclic arginine-glycine-aspartate (RGD) peptide, a tetraethylene glycol spacer, and a gallate moiety was designed, synthesized, and characterized.
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