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Y0001611

Esculetin

Name: Esculetin
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

6,7-Dihydroxycoumarin, Cichorigenin, Esculetin

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About This Item

Empirical Formula (Hill Notation):

C₉H₆O₄

CAS Number:

305-01-1

Molecular Weight:

178.14

Beilstein:

152788

MDL number:

MFCD00006874

UNSPSC Code:

41116107

PubChem Substance ID:

329831510

NACRES:

NA.24

grade

pharmaceutical primary standard

API family

esculetin

manufacturer/tradename

EDQM

mp

271-273 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

Oc1cc2OC(=O)C=Cc2cc1O

InChI

1S/C9H6O4/c10-6-3-5-1-2-9(12)13-8(5)4-7(6)11/h1-4,10-11H

InChI key

ILEDWLMCKZNDJK-UHFFFAOYSA-N

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Analytical Reference Standards

Pharmacopeia & Metrological Institute Standards

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Esculetin EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Esculetin induces antiproliferative and apoptotic response in pancreatic cancer cells by directly binding to KEAP1.

Rashi Arora et al.

Molecular cancer, 15(1), 64-64 (2016-10-21)

A handful of studies have exploited antitumor potential of esculetin, a dihydroxy coumarine derivative; the targets to which it binds and the possible downstream mechanism for its cytotoxicity in cancer cells remain to be elucidated. Using pancreatic cancer cell lines

In vitro assessment of mutagenic and genotoxic effects of coumarin derivatives 6,7-dihydroxycoumarin and 4-methylesculetin.

Edson Luis Maistro et al.

Journal of toxicology and environmental health. Part A, 78(2), 109-118 (2014-11-27)

Coumarins are naturally occurring compounds, widely distributed throughout the plant kingdom (Plantae), and possess important pharmacological properties, including inhibition of oxidative stress. In this context, newly synthesized coumarin compounds are being produced due to their potent antioxidant activities. Therefore, the

The in vivo effect of esculetin ointment and esculetin-mixed Zyderm for Zyderm.

Hisayo Yamaoka et al.

Plastic and reconstructive surgery, 134(1), 50e-58e (2014-07-17)

Injectable collagen is often used for treatment of wrinkles or scars in cosmetic surgery. However, it is degraded within a short period after subcutaneous injection. The authors aimed to achieve a long-lasting effect of the filler with a new collagenase

Viola mandshurica ethanolic extract prevents high-fat-diet-induced obesity in mice by activating AMP-activated protein kinase.

Yoon-Young Sung et al.

Environmental toxicology and pharmacology, 38(1), 41-50 (2014-06-01)

Viola mandshurica W. Becker has been used as an expectorant, diuretic, and anti-inflammatory agent. We evaluated the effects of V. mandshurica ethanol extract (VME) on high-fat-diet (HFD)-induced obesity in mice. HPLC analysis showed that the VME contained 11.95 ± 0.37

Ectopic expression of a stress-inducible glycosyltransferase from saffron enhances salt and oxidative stress tolerance in Arabidopsis while alters anchor root formation.

Oussama Ahrazem et al.

Plant science : an international journal of experimental plant biology, 234, 60-73 (2015-03-26)

Glycosyltransferases play diverse roles in cellular metabolism by modifying the activities of regulatory metabolites. Three stress-regulated UDP-glucosyltransferase-encoding genes have been isolated from the stigmas of saffron, UGT85U1, UGT85U2 and UGT85V1, which belong to the UGT85 family that includes members associated

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