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Y0001243

Folic acid impurity D

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Pteroic acid

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About This Item

Empirical Formula (Hill Notation):
C14H12N6O3
CAS Number:
119-24-4
Molecular Weight:
312.28
MDL number:
MFCD00075823
UNSPSC Code:
41116107
PubChem Substance ID:
329831320
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

folic acid

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

NC1=NC(=O)C2=NC(CNc3ccc(cc3)C(O)=O)=CNC2=N1

InChI

1S/C14H12N6O3/c15-14-19-11-10(12(21)20-14)18-9(6-17-11)5-16-8-3-1-7(2-4-8)13(22)23/h1-4,6,16H,5H2,(H,22,23)(H3,15,17,19,20,21)

InChI key

JOAQINSXLLMRCV-UHFFFAOYSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Folic acid impurity D EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Kerim Babaoglu et al.
Structure (London, England : 1993), 12(9), 1705-1717 (2004-09-03)
Dihydropterate synthase (DHPS) is the target for the sulfonamide class of antibiotics, but increasing resistance has encouraged the development of new therapeutic agents against this enzyme. One approach is to identify molecules that occupy the pterin binding pocket which is
Application of halogeno-ketones to the synthesis of pteridines, including pteroic acid.
F E KING et al.
Nature, 164(4170), 574-574 (1949-10-01)
H S Tillinghast et al.
Journal of cell science, 87 ( Pt 1), 45-53 (1987-02-01)
Following a previous study indicating a sensitivity to folate during the developmental phase of Dictyostelium discoideum, a series of pteridines were investigated for their ability to induce amoebal chemotaxis during development of this organism. Several compounds were found to resemble
H Oe et al.
Journal of nutritional science and vitaminology, 29(5), 523-531 (1983-10-01)
A sensitive radioassay method has been developed to quantitate the activity of the folate-hydrolyzing enzyme which catalyzes the hydrolysis of folic acid to pteroic acid and glutamic acid. The method is based on analyzing [2-14C]pteroic acid separated by a thin-layer
R L Stephens et al.
The Journal of pharmacology and experimental therapeutics, 239(3), 627-633 (1986-12-01)
Folic acid (FA) and 5-formyltetrahydrofolic acid (FTHF) have been shown previously to produce a marked stimulation of locomotor activity after bilateral injection into the rat nucleus accumbens. This study was designed to determine whether the hypermotility response produced by the
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