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Y0001025

Benazepril hydrochloride

European Pharmacopoeia (EP) Reference Standard

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Synonym(s):
(3S)-3-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid hydrochloride
Empirical Formula (Hill Notation):
C24H28N2O5 · HCl
CAS Number:
86541-74-4
Molecular Weight:
460.95
MDL number:
MFCD00895734
UNSPSC Code:
41116107
PubChem Substance ID:
329831225
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

benazepril

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

Cl[H].CCOC(=O)[C@H](CCc1ccccc1)N[C@H]2CCc3ccccc3N(CC(O)=O)C2=O

InChI

1S/C24H28N2O5.ClH/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28;/h3-11,19-20,25H,2,12-16H2,1H3,(H,27,28);1H/t19-,20-;/m0./s1

InChI key

VPSRQEHTHIMDQM-FKLPMGAJSA-N

Gene Information

human ... ACE(1636)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Benazepril hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Benazepril is a long-acting angiotensin converting enzyme (ACE) inhibitor.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

related product

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Benazepril impurity A, European Pharmacopoeia (EP) Reference Standard

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Benazepril Related Compound G, United States Pharmacopeia (USP) Reference Standard

1048674

Benazepril Related Compound F, United States Pharmacopeia (USP) Reference Standard

1048620

Benazepril Related Compound A, United States Pharmacopeia (USP) Reference Standard

1048619

Benazepril hydrochloride, United States Pharmacopeia (USP) Reference Standard

1048652

Benazepril Related Compound D, United States Pharmacopeia (USP) Reference Standard

1048663

Benazepril Related Compound E, United States Pharmacopeia (USP) Reference Standard

1048641

Benazepril Related Compound C, United States Pharmacopeia (USP) Reference Standard

1048630

Benazepril Related Compound B, United States Pharmacopeia (USP) Reference Standard

PHR1912

Benazepril hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2422

Benazepril Related Compound E, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2423

Benazepril Related Compound F, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2922

Benazepril Related Compound D, certified reference material, pharmaceutical secondary standard

PHR2930

Benazepril Related Compound G, certified reference material, pharmaceutical secondary standard

PHR8937

Benazepril Related Compound B, Pharmaceutical Secondary Standard; Certified Reference Material

PHR8936

Benazepril Related Compound A, Pharmaceutical Secondary Standard; Certified Reference Material

Pictograms

Health hazard
GHS08

Signal Word

Warning

Hazard Statements

H361fd

Hazard Classifications

Repr. 2

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Application of LC and HPTLC-densitometry for the simultaneous determination of benazepril hydrochloride and hydrochlorothiazide.
El-Gindy A, et al.
Journal of Pharmaceutical and Biomedical Analysis, 25(2), 171-179 (2001)
Simultaneous determination of benazepril hydrochloride and hydrochlorothiazide in tablets by second-order derivative spectrophotometry.
Panderi E I.
Journal of Pharmaceutical and Biomedical Analysis, 21(2), 257-265 (1999)
Bjoern B Burckhardt et al.
Journal of pharmaceutical and biomedical analysis, 96, 118-126 (2014-04-18)
Although serum and plasma are the biological fluids of choice for pharmacokinetic determination of drugs in adults, it is desirable to elucidate noninvasive methods which can be used for investigations in vulnerable groups such as children. If the drug properties
Bjoern B Burckhardt et al.
Biomedical chromatography : BMC, 28(12), 1679-1691 (2014-05-03)
The benefit-risk ratio of combined blocking by the direct renin inhibitor aliskiren and an angiotensin-converting enzyme inhibitor (e.g. enalapril) on the renin-angiotensin-aldosterone system is discussed. No method was available for simultaneous determination of both drugs in urine. A novel sensitive
Haruka Nishimuta et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(9), 1522-1531 (2014-07-06)
Hydrolysis plays an important role in metabolic activation of prodrugs. In the current study, species and in vitro system differences in hepatic and extrahepatic hydrolysis were investigated for 11 prodrugs. Ten prodrugs in the data set are predominantly hydrolyzed by

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