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Merck
CN

Y0001006

Dydrogesterone impurity B

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Pregna-4,6-diene-3,20-dione

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About This Item

Empirical Formula (Hill Notation):
C21H28O2
CAS Number:
1162-56-7
Molecular Weight:
312.45
UNSPSC Code:
41116107
NACRES:
NA.24

Key Documents

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SMILES string

O=C1CC[C@@]2([C@@H]3[C@H]([C@H]4[C@@]([C@H](CC4)C(=O)C)(CC3)C)C=CC2=C1)C

InChI

1S/C21H28O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4-5,12,16-19H,6-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1

InChI key

JGMOKGBVKVMRFX-LEKSSAKUSA-N

grade

pharmaceutical primary standard

API family

dydrogesterone

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Related Categories

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Dydrogesterone impurity B EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

pictograms

Health hazard
GHS08

signalword

Danger

Hazard Classifications

Carc. 2 - Lact. - Repr. 1A

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

涉药品监管产品
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Ireneusz Polac et al.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 27(9), 692-695 (2010-10-29)
Hormone therapy (HT) can be prothrombotic risk factor. We compared the effects of oral HT (o-HT) and transdermal HT (t-HT) on the kinetic of clot formation and fibrinolysis in postmenopausal women after 6 months HT using a multiparameter test. We
Zahiruddin Othman et al.
Menopause (New York, N.Y.), 18(11), 1219-1224 (2011-09-20)
The aim of this study was to evaluate the verbal learning and memory performance of postmenopausal women who received tualang honey (Agro Mas) in comparison with women receiving estrogen plus progestin therapy and untreated controls. A total of 102 postmenopausal
Ashalatha Ganesh et al.
Fertility and sterility, 95(6), 1961-1965 (2011-02-22)
To compare the efficacy of oral dydrogesterone with that of micronized vaginal P gel and micronized P capsule for luteal supplementation. Prospective, randomized clinical study. Institute of Reproductive Medicine, Kolkata, India. A total of 1,373 infertile women undergoing IVF participated.
M V Suknovalova et al.
Eksperimental'naia i klinicheskaia farmakologiia, 76(7), 24-26 (2013-09-07)
It has been shown that specific binding of dydrogesterone with progesterone receptors in blood mononuclear cells of the patients included in the programs of in vitro fertilization, varies from 0 to 298%, thus at 38% of women dydrogesterone concedes to
Xiao-Dong Fu et al.
Molecular human reproduction, 18(1), 44-51 (2011-10-06)
Clinical observations and basic studies show that progesterone and progestins have a variable influence on endothelial function. Dydrogesterone (DG) is a widely used progestin, but its endothelial actions have not been thoroughly assessed. In this study, we investigated the effects
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