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Y0000775

Benzbromarone

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethylbenzofuran

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About This Item

Empirical Formula (Hill Notation):
C17H12Br2O3
CAS Number:
3562-84-3
Molecular Weight:
424.08
MDL number:
MFCD00078962
UNSPSC Code:
41116107
PubChem Substance ID:
329831145
NACRES:
NA.24
Pricing and availability is not currently available.

grade

pharmaceutical primary standard

API family

benzbromarone

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

CCc1oc2ccccc2c1C(=O)c3cc(Br)c(O)c(Br)c3

InChI

1S/C17H12Br2O3/c1-2-13-15(10-5-3-4-6-14(10)22-13)16(20)9-7-11(18)17(21)12(19)8-9/h3-8,21H,2H2,1H3

InChI key

WHQCHUCQKNIQEC-UHFFFAOYSA-N

Gene Information

human ... SLC22A12(116085)

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Show Differences

1 of 4

This Item
07102320331258148
盐酸 puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., fuming, ≥37%, APHA: ≤10

30721

盐酸

盐酸 meets analytical specification of Ph. Eur., BP, NF, fuming, 36.5-38%

07102

盐酸

盐酸 ACS reagent, 37%

320331

盐酸

盐酸 ACS reagent, 37%

258148

盐酸

assay

≥37%

assay

36.5-38%

assay

36.5-38.0% (ACS specification), 37%

assay

36.5-38.0% (ACS specification), 37%

agency

USP/NF, reag. Ph. Eur., reag. ISO

agency

-

agency

suitable for GB 5009.253-2016, suitable for SM 5210

agency

suitable for GB 5009.253-2016, suitable for SM 5210

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

form

liquid

form

liquid

form

liquid

form

liquid

bp

>100 °C (lit.)

bp

>100 °C (lit.)

bp

>100 °C (lit.)

bp

>100 °C (lit.)

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Benzbromarone EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301

Precautionary Statements

P301 + P310 + P330

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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    Dingyu Wang et al.
    Cardiovascular toxicology, 21(3), 192-205 (2020-10-26)
    High levels of serum uric acid is closely associated with atrial fibrillation (AF); nonetheless, the detailed mechanisms remain unknown. Therefore, this work examined the intricate mechanisms of AF triggered by hyperuricemia and the impact of the uricosuric agent benzbromarone on
    Kaoru Kobayashi et al.
    Biopharmaceutics & drug disposition, 33(8), 466-473 (2012-08-31)
    Benzbromarone (BBR) is metabolized to 1'-hydroxy BBR and 6-hydroxy BBR in the liver. 6-Hydroxy BBR is further metabolized to 5,6-dihydroxy BBR. The aim of this study was to identify the CYP isozymes involved in the metabolism of BBR to 1'-hydroxy
    Zhijian Lin et al.
    Journal of medicinal food, 17(11), 1214-1221 (2014-10-15)
    Inulin, a group of dietary fibers, is reported to improve the metabolic disorders. In the present study, we investigated the effects of chicory inulin on serum metabolites of uric acid (UA), lipids, glucose, and abdominal fat deposition in quail model
    Ming-Han H Lee et al.
    Drug safety, 31(8), 643-665 (2008-07-19)
    Benzbromarone, a potent uricosuric drug, was introduced in the 1970s and was viewed as having few associated serious adverse reactions. It was registered in about 20 countries throughout Asia, South America and Europe. In 2003, the drug was withdrawn by
    Tip W Loo et al.
    Biochemistry, 50(21), 4393-4395 (2011-04-28)
    Deletion of Phe508 from the first nucleotide-binding domain of the CFTR chloride channel causes cystic fibrosis because it inhibits protein folding. Indirect approaches such as incubation at low temperatures can partially rescue ΔF508 CFTR, but the protein is unstable at
    View All Related Papers

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