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COO/COA

Y0000737

Flavoxate impurity A

Name: Flavoxate impurity A
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

3-Methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylic acid

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₁₂O₄

CAS Number:

3468-01-7

Molecular Weight:

280.27

UNSPSC Code:

41116107

NACRES:

NA.24

grade

pharmaceutical primary standard

API family

flavoxate

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

InChI

1S/C17H12O4/c1-10-14(18)12-8-5-9-13(17(19)20)16(12)21-15(10)11-6-3-2-4-7-11/h2-9H,1H3,(H,19,20)

InChI key

KMMBBZOSQNLLMN-UHFFFAOYSA-N

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Analytical Reference Standards

Pharmacopeia & Metrological Institute Standards

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Flavoxate impurity A EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

related product

Product No.

Description

Pricing

1270719

1270731

1270720

BP571

Flavoxate hydrochloride, British Pharmacopoeia (BP) Reference Standard

BP569

3-Methylflavone-8-carboxylic acid, British Pharmacopoeia (BP) Reference Standard

PHR3008

Pictograms

GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Precautionary Statements

P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Lot/Batch Number

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Antispasmodic effects of flavoxate, MFCA, and REC 15/2053 on smooth muscle of human prostate and urinary bladder.

M Caine et al.

Urology, 37(4), 390-394 (1991-04-01)

The antispasmodic effects of the flavone compounds flavoxate hydrochloride, 3-methylflavone carboxylic acid (MFCA), and REC 15/2053 (and in the case of the detrusor, oxybutynin), on the human detrusor, prostatic adenoma, prostatic capsule, and bladder neck, were studied by the in

Determination of 3-methylflavone-8-carboxylic acid, the main metabolite of flavoxate, in human urine by capillary electrophoresis with direct injection.

C X Zhang et al.

Journal of chromatography, 612(2), 287-294 (1993-02-26)

The effects of tetraalkylammonium salts and sodium dodecyl sulphate on the migration behaviour of human urinary components and other negatively charged or neutral solutes were investigated. The sulphate acted mainly on hydrophobic and positively charged substances, whereas the ammonium salts

Pharmacological activities of the main metabolite of flavoxate 3-methylflavone-8-carboxylic acid.

P Cazzulani et al.

Arzneimittel-Forschung, 38(3), 379-382 (1988-03-01)

The pharmacological properties of 3-methylflavone-8-carboxylic acid (MFCA), the main metabolite of flavoxate, have been studied in vitro and in vivo. MFCA did not display antispasmodic activity on isolated organs contractions induced by histamine, acetylcholine or CaCl2, nor did it exhibit

High-performance liquid chromatographic determination of flavoxate hydrochloride and its hydrolysis product.

Alaa el-Gindy et al.

Drug development and industrial pharmacy, 34(12), 1311-1322 (2008-10-14)

Liquid chromatographic method was presented for the determination of flavoxate hydrochloride (FX) and its hydrolysis product. The method was based on high-performance liquid chromatographic (HPLC) separation of FX from its hydrolysis product on CN column using a mobile phase consisting

Molecularly imprinted polymer for selective extraction of 3-methylflavone-8-carboxylic acid from human urine followed by its determination using zwitterionic hydrophilic interaction liquid chromatography.

Ramisetti N Rao et al.

Journal of separation science, 34(22), 3265-3271 (2011-10-15)

A novel water-compatible molecularly imprinted SPE combined with zwitterionic hydrophilic interaction liquid chromatography method for selective extraction and determination of 3-methylflavone-8-carboxylic acid (MFA), the main active metabolite of flavoxate in human urine, was developed and validated. The effects of progenic

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