All Photos(1)

Documents

COO/COA

Y0000664

Methotrexate impurity E

Name: Methotrexate impurity E
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

4-{[(2,4-Diaminopteridin-6-yl)methyl]methylamino}benzoic acid

Sign Into View Organizational & Contract Pricing

All Photos(1)

About This Item

Empirical Formula (Hill Notation):

C₁₅H₁₄N₇O₂

CAS Number:

19741-14-1

Molecular Weight:

324.32

UNSPSC Code:

41116107

NACRES:

NA.24

grade

pharmaceutical primary standard

API family

methotrexate

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

InChI

1S/C15H15N7O2/c1-22(10-4-2-8(3-5-10)14(23)24)7-9-6-18-13-11(19-9)12(16)20-15(17)21-13/h2-6H,7H2,1H3,(H,23,24)(H4,16,17,18,20,21)

InChI key

LWCXZSDKANNOAR-UHFFFAOYSA-N

Related Categories

Analytical Reference Standards

Exclusive Savings

Pharmacopeia & Metrological Institute Standards

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Methotrexate impurity E EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

related product

Product No.

Description

Pricing

1414025

1414036

1414058

Pictograms

GHS06,GHS08

Signal Word

Danger

Hazard Statements

H301,H315,H319,H341,H360D

Precautionary Statements

P202 - P264 - P270 - P301 + P310 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Muta. 2 - Repr. 1B - Skin Irrit. 2

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Sorry, we don't have COAs for this product available online at this time.

If you need assistance, please contact Customer Support.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Commentary.

Michael C Milone

Clinical chemistry, 56(12), 1795-1796 (2010-12-02)

High-performance liquid chromatographic assay of methotrexate, 7-hydroxymethortrexate, 4-deoxy-4-amino-N10-methylpteroic acid and sulfamethoxazole in serum, urine and cerebrospinal fluid.

D A Cairnes et al.

Journal of chromatography, 231(1), 103-110 (1982-08-13)

An automated high-performance liquid chromatographic system is described for separation and quantitation of the antineoplastic drug methotrexate and metabolites, and the antibiotic sulfamethoxazole in body fluids. The 40-min analysis utilizes a reversed-phase C18 column and gradient elution with detection by

Hepatic methotrexate content and progression of hepatic fibrosis: preliminary findings.

M J Ahern et al.

Annals of the rheumatic diseases, 50(7), 477-480 (1991-07-01)

Liver tissue from 16 patients with rheumatoid arthritis was studied. The patients had received low dose methotrexate weekly for a minimum of 12 months between two liver biopsies. The progression of pericellular fibrosis was measured by computerised image analysis. Extracts

Carboxypeptidase G2 rescue after high-dose methotrexate.

L M DeAngelis et al.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 14(7), 2145-2149 (1996-07-01)

This study was a pilot project to assess the safety and efficacy of carboxypeptidase G2 (CPG2) rescue from high-dose (HD) methotrexate (MTX) in patients with recurrent cerebral lymphoma. Four patients with recurrent primary CNS lymphoma (PCNSL) were studied. Patients received

Mass spectrometry of permethylated folic acid analogs.

R G Smith et al.

Biomedical mass spectrometry, 8(4), 144-148 (1981-04-01)

Folic acid and several analogs have been characterized as their permethylated derivatives. These derivatives are readily evaporated from the solid probe and provide spectra with abundant molecular ions and characteristic fragment ions. This method has been used to confirm the

View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service