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Merck
CN

Y0000621

Terazosin hydrochloride dihydrate

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]piperazine hydrochloride dihydrate

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About This Item

Empirical Formula (Hill Notation):
C19H25N5O4 · HCl · 2H2O
CAS Number:
70024-40-7
Molecular Weight:
459.92
NACRES:
NA.24
PubChem Substance ID:
329831056
UNSPSC Code:
41116107
MDL number:
MFCD00941408

Key Documents

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InChI key

NZMOFYDMGFQZLS-UHFFFAOYSA-N

SMILES string

O.O.Cl.COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)C4CCCO4

InChI

1S/C19H25N5O4.ClH.2H2O/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;;;/h10-11,14H,3-9H2,1-2H3,(H2,20,21,22);1H;2*1H2

grade

pharmaceutical primary standard

API family

terazosin

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)

Related Categories

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Terazosin hydrochloride dihydrate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319

Hazard Classifications

Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Cabir Alan et al.
Urology, 77(6), 1439-1443 (2011-01-25)
To investigate the effects of alpha receptor blockers used in the treatment of benign prostatic hyperplasia (BPH) on endothelial functions, coagulation parameters, and arterial blood pressure. One-hundred fifteen patients admitted to the treatment protocol because of symptomatic BPH were included
Ali Ghaleiha et al.
International journal of psychiatry in clinical practice, 17(1), 44-47 (2012-06-27)
By considering the role of adrenergic nervous system in sweat secretion, we postulated that terazosin may be able to improve sweating after taking sertraline, a selective serotonin reuptake inhibitor (SSRI) drug. This study was designed to evaluate the effect of
Arash Tadjalli et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(50), 16886-16895 (2010-12-17)
The respiratory control system is not just reflexive, it is smart, it learns, and, in fact, it has a memory. The respiratory system listens to and carefully remembers how previous stimuli affect breathing. Respiratory memory is laid down by adjusting
Man Liu et al.
Chirality, 24(12), 1047-1050 (2012-08-14)
The purpose of this study was to elucidate the pharmacokinetics of terazosin enantiomers in healthy Chinese male subjects. After a single oral dose of 2-mg terazosin, the plasma concentrations of terazosin enantiomers were measured over the course of 48 h
Laurel E Ecke et al.
Neuroreport, 23(5), 325-330 (2012-02-18)
The rewarding properties of psychomotor stimulants are traditionally thought to be independent of norepinephrine. Recent findings, however, suggest that local noradrenergic signaling through α1 receptors in the medial prefrontal cortex and the ventral tegmental area - brain regions critically important
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