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Y0000563

Amitriptyline hydrochloride

European Pharmacopoeia (EP) Reference Standard

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Synonym(s):
AMT
Empirical Formula (Hill Notation):
C20H23N · HCl
CAS Number:
549-18-8
Molecular Weight:
313.86
MDL number:
MFCD00012537
UNSPSC Code:
41116107
PubChem Substance ID:
329831024
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

amitriptyline

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

Cl[H].CN(C)CC\C=C1\c2ccccc2CCc3ccccc13

InChI

1S/C20H23N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-12H,7,13-15H2,1-2H3;1H

InChI key

KFYRPLNVJVHZGT-UHFFFAOYSA-N

Gene Information

human ... SLC6A2(6530) , SLC6A4(6532)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Amitriptyline hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Tricyclic antidepressant; inhibits the norepinephrine and serotonin transporters with Kis of 100 nM and 14.7 nM, respectively; high in vitro affinity for α1-adrenoceptors, serotonin and muscarinic acetylcholine receptors.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

related product

Product No.
Description
Pricing

1029002

Amitriptyline hydrochloride, United States Pharmacopeia (USP) Reference Standard

D1000000

Dibenzosuberone, European Pharmacopoeia (EP) Reference Standard

1029013

Amitriptyline Related Compound A, United States Pharmacopeia (USP) Reference Standard

1029024

Amitriptyline Related Compound B, United States Pharmacopeia (USP) Reference Standard

PHR1776

Amitriptyline Related Compound B, Pharmaceutical Secondary Standard; Certified Reference Material

BP016

Amitriptyline hydrochloride, British Pharmacopoeia (BP) Reference Standard

BP858

Dibenzosuberone, British Pharmacopoeia (BP) Reference Standard

PHR2836

Amitriptyline Related Compound A, certified reference material, pharmaceutical secondary standard

Signal Word

Danger

Hazard Statements

H301,H319,H361d,H410

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Repr. 2

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Quantitative analysis of amitriptyline and nortriptyline in human plasma and liver microsomal preparations by high-performance liquid chromatography.
Ghahramani P, et al.
Journal of Chromatography. B, Biomedical Applications, 685(2), 307-313 (1996)
Interaction of amphiphilic drug amitriptyline hydrochloride with β-cyclodextrin as studied by conductometry, surface tensiometry and viscometry.
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