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Y0000487

Leflunomide impurity A

European Pharmacopoeia (EP) Reference Standard

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Synonym(s):
4-(Trifluoromethyl)aniline, α,α,α-Trifluoro-p-toluidine, 4-Aminobenzotrifluoride
Linear Formula:
CF3C6H4NH2
CAS Number:
455-14-1
Molecular Weight:
161.12
Beilstein:
1564853
MDL number:
MFCD00064396
UNSPSC Code:
41116107
PubChem Substance ID:
329830979
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

leflunomide

manufacturer/tradename

EDQM

refractive index

n20/D 1.483 (lit.)

bp

83 °C/12 mmHg (lit.)

density

1.283 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

Nc1ccc(cc1)C(F)(F)F

InChI

1S/C7H6F3N/c8-7(9,10)5-1-3-6(11)4-2-5/h1-4H,11H2

InChI key

ODGIMMLDVSWADK-UHFFFAOYSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Leflunomide impurity A EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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Signal Word

Danger

Hazard Statements

H301,H318,H410

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1

WGK

WGK 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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P M Sharp
Gene, 139(1), 135-136 (1994-02-11)
Three previously unrecognized genes from Bacillus licheniformis, Thermus thermophilus and Thermotoga maritima, encoding ribosomal protein L33, have been identified and designated as rpmG genes. Their sequence and context have been compared with the three known rpmG genes from Escherichia coli
S H Coleman et al.
Journal of general microbiology, 139(4), 707-716 (1993-04-01)
The rpmB,G operon of Escherichia coli codes for the synthesis of ribosomal proteins L28 and L33. In one mutant strain (TP28), these two proteins are made at about half their normal rates, ribosome assembly is greatly perturbed and precursor particles
Giorgio Mangiarotti
Biochemistry and cell biology = Biochimie et biologie cellulaire, 80(2), 261-270 (2002-05-07)
Ribosomal protein mRNAs left over from growth are selectively excluded from polyribosomes in the first half of Dictyostelium discoideum development. This is due to the fact that they are sequestered by a class of free 40S ribosomal subunits, characterized by
Ribosomal proteins S3a, S13, S16, and S24 are not mutated in patients with Diamond-Blackfan anemia.
R Cmejla et al.
Blood, 97(2), 579-580 (2001-02-24)
L Sebestová et al.
Toxicology, 92(1-3), 27-38 (1994-09-06)
Three isomers of trifluoromethylaniline (TFMA) were investigated for their possible different toxic effects on the hematopoietic system in male Wistar rats. The effects of isomeric 2-, 3- and 4-TFMA were compared with those of aniline, the prototypic drug. Strong leukocytosis
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