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Merck
CN

Y0000405

Salicylic acid impurity B

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

4-Hydroxyisophthalic acid, 4-Hydroxy 1,3-benzenedicarboxylic acid

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About This Item

Linear Formula:
HOC6H3-1,3-(CO2H)2
CAS Number:
636-46-4
Molecular Weight:
182.13
NACRES:
NA.24
PubChem Substance ID:
329830938
UNSPSC Code:
41116107
MDL number:
MFCD00010391

Key Documents

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Product Name

Salicylic acid impurity B, European Pharmacopoeia (EP) Reference Standard

InChI

1S/C8H6O5/c9-6-2-1-4(7(10)11)3-5(6)8(12)13/h1-3,9H,(H,10,11)(H,12,13)

SMILES string

OC(C1=CC(C(O)=O)=C(O)C=C1)=O

InChI key

BCEQKAQCUWUNML-UHFFFAOYSA-N

grade

pharmaceutical primary standard

API family

salicylic acid

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

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Related Categories

Application

Salicylic acid impurity B EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

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[In vitro study of the effects of various 4-hydroxyisophthalic acid derivatives on human platelet aggregation].
M De Cunto et al.
Bollettino della Societa italiana di biologia sperimentale, 59(3), 302-308 (1983-03-30)
E Piscopo et al.
Bollettino della Societa italiana di biologia sperimentale, 60(6), 1169-1175 (1984-06-30)
The following hydrazono derivatives (I-XIX) of type (A) (sequence in text) where Rn = (sequence in text ) (I-XVII); (sequence in text) (XVIII); -CCl3 (XIX); and Xn = H (I); 2-Cl (II); 3-Cl (III); 4-Cl (IV); 2-NO2 (V); 3-NO2 (VI);
E Piscopo et al.
Bollettino della Societa italiana di biologia sperimentale, 60(12), 2273-2279 (1984-12-30)
A series of 1,3 -bis-anilides of 4-hydroxyisophthalic acid was prepared and tested for antibacterial and antifungal activity. The prepared compounds (I-XVIII), of general structure (A), (Formula: see text) where Xn = H (I); 2-F (II); 3-F (III); 4-F (IV); 2-Cl
[In vitro study of the mechanism of the platelet anti-aggregant action of picotamide (G 137)].
M Berrettini et al.
Bollettino della Societa italiana di biologia sperimentale, 59(3), 309-315 (1983-03-30)
C P Saint et al.
FEMS microbiology letters, 57(3), 323-328 (1990-06-01)
Genes involved in 4-methyl-o-phthalate and 4-hydroxy-iso-phthalate catabolism reside on a 226-232 kbp catabolic plasmid termed MOP. This was confirmed by transformation and conjugation into an isogenic heat-cured (MOP-) derivative of the wild-type isolate, identified and termed Pseudomonas cepacia Pc701. Transformation

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