Skip to Content
Merck
CN
All Photos(1)

Key Documents

View All Documentation

Safety Information

Y0000396

Granisetron hydrochloride

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

1-Methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide hydrochloride

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C18H24N4O· HCl
CAS Number:
107007-99-8
Molecular Weight:
348.87
MDL number:
MFCD01747034
UNSPSC Code:
41116107
PubChem Substance ID:
329830931
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

granisetron

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

Cl.CN1[C@H]2CCC[C@@H]1C[C@@H](C2)NC(=O)c3nn(C)c4ccccc34

InChI

1S/C18H24N4O.ClH/c1-21-13-6-5-7-14(21)11-12(10-13)19-18(23)17-15-8-3-4-9-16(15)22(2)20-17;/h3-4,8-9,12-14H,5-7,10-11H2,1-2H3,(H,19,23);1H/t12-,13+,14-;

InChI key

QYZRTBKYBJRGJB-WQTKJZBYSA-N

Looking for similar products? Visit Product Comparison Guide

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Granisetron hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Granisetron hydrochloride is a serotonin 5-HT3 receptor antagonist and antiemetic.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

related product

Product No.
Description
Pricing

Y0000395

Granisetron impurity E, European Pharmacopoeia (EP) Reference Standard

Y0000477

Granisetron impurity A, European Pharmacopoeia (EP) Reference Standard

Y0000478

Granisetron impurity B, European Pharmacopoeia (EP) Reference Standard

1298140

Granisetron Related Compound D, United States Pharmacopeia (USP) Reference Standard

1298117

Granisetron Related Compound A, United States Pharmacopeia (USP) Reference Standard

1298128

Granisetron Related Compound B, United States Pharmacopeia (USP) Reference Standard

1298106

Granisetron hydrochloride, United States Pharmacopeia (USP) Reference Standard

1298139

Granisetron Related Compound C, United States Pharmacopeia (USP) Reference Standard

1298150

Granisetron Related Compound E, United States Pharmacopeia (USP) Reference Standard

1298092

Granisetron, United States Pharmacopeia (USP) Reference Standard

PHR2871

Granisetron Related Compound D, pharmaceutical secondary standard, certified reference material

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P301 + P312 + P330

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

监管及禁止进口产品

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Sorry, we don't have COAs for this product available online at this time.

If you need assistance, please contact Customer Support.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Mohammad-Reza Khodaie-Ardakani et al.
Journal of psychiatric research, 47(4), 472-478 (2013-02-05)
Some 5-HT3 antagonists such as ondansetron have shown beneficial effects on negative symptoms of patients with schizophrenia. We aimed to evaluate the efficacy of granisetron (another 5-HT3 antagonist) add-on therapy in the treatment of negative symptoms of patients with stable
Hea-Jeong Doh et al.
Colloids and surfaces. B, Biointerfaces, 101, 475-480 (2012-09-27)
A new lipid nanoemulsion (LNE) system containing granisetron (GRN) was developed and its in vitro permeation-enhancing effect was evaluated using Caco-2 cell monolayers. Particle size, polydispersity index (PI) and stability of the prepared GRN-loaded LNE systems were also characterized. The
Divya Kesters et al.
EMBO reports, 14(1), 49-56 (2012-12-01)
The 5-HT(3) receptor is a pentameric serotonin-gated ion channel, which mediates rapid excitatory neurotransmission and is the target of a therapeutically important class of anti-emetic drugs, such as granisetron. We report crystal structures of a binding protein engineered to recognize
Su Mi Park et al.
Reviews in the neurosciences, 23(5-6), 555-569 (2012-10-23)
The changes in serotonin type 3 (5-HT) receptor activity influence memory and emotional regulation,the two essential components underlying the successful extinction of conditioned fear. These studies determined if blocking 5-HT3 receptors with granisetron influences the extinction of fear in male
Yuko Horii et al.
Neuroscience letters, 539, 32-37 (2013-02-09)
Lactobacilli provide several health benefits to mammals, including humans. We previously observed that in rats, intraduodenal injection of Lactobacillus johnsonii La1 elevated efferent gastric vagal nerve activity (efferent-GVNA), while Lactobacillus paracasei ST11 suppressed efferent-GVNA, and thereby increased or decreased food
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service