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Y0000352

Beclometasone dipropionate for system suitability

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Beclomethasone dipropionate, 9-Chloro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate

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About This Item

Empirical Formula (Hill Notation):
C28H37ClO7
CAS Number:
5534-09-8
Molecular Weight:
521.04
MDL number:
MFCD00135613
UNSPSC Code:
41116107
PubChem Substance ID:
329830914
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

beclometasone

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

CCC(=O)OCC(=O)[C@@]1(OC(=O)CC)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@]12C

InChI

1S/C28H37ClO7/c1-6-23(33)35-15-22(32)28(36-24(34)7-2)16(3)12-20-19-9-8-17-13-18(30)10-11-25(17,4)27(19,29)21(31)14-26(20,28)5/h10-11,13,16,19-21,31H,6-9,12,14-15H2,1-5H3/t16-,19-,20-,21-,25-,26-,27-,28-/m0/s1

InChI key

KUVIULQEHSCUHY-XYWKZLDCSA-N

Gene Information

human ... NR3C1(2908)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Beclometasone dipropionate for system suitability EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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Pictograms

Health hazard
GHS08

Signal Word

Warning

Hazard Statements

H361fd,H373

Hazard Classifications

Repr. 2 - STOT RE 2

Target Organs

Adrenal gland,Immune system,Bone

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

监管及禁止进口产品

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Certificates of Analysis (COA)

Lot/Batch Number

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T B Edwards
Clinical therapeutics, 17(6), 1032-1041 (1995-11-01)
There is an increasing trend toward topical intranasal corticosteroids as the preferred treatment for seasonal or perennial allergic rhinitis. This trend is based on the fact that the chronic, mucosal inflammation that accompanies allergic rhinitis responds to anti-inflammatory drugs such
Effect of inhaled beclomethasone dipropionate and budesonide on adrenal function, skin changes and cataract formation.
R G Dluhy
Respiratory medicine, 92 Suppl B, 15-23 (1999-04-08)
J C Guérin et al.
Presse medicale (Paris, France : 1983), 21(32), 1526-1531 (1992-10-03)
Beclomethasone dipropionate has now been used for more than 10 years during which our knowledge of how to use inhaled corticosteroids has gradually improved: high dose initial treatment followed by progressive reduction down to the minimum effective dosage; administration in
Efficacy of inhaled beclomethasone dipropionate and budesonide in the treatment of asthma.
D R Webb
Respiratory medicine, 92 Suppl B, 7-14 (1999-04-08)
Comparative review of the effects of inhaled beclomethasone dipropionate and budesonide on bone.
M D'Souza
Respiratory medicine, 92 Suppl B, 24-36 (1999-04-08)
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