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Y0000207

Perindopril for stereochemical purity

Name: Perindopril for stereochemical purity
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Perindopril erbumine, (2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)butyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic acid tert-butylamine salt, Perindopril tert-butylamine, S-9490

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About This Item

Empirical Formula (Hill Notation):

C₁₉H₃₂N₂O₅· C₄H₁₁N

CAS Number:

107133-36-8

Molecular Weight:

441.60

MDL number:

MFCD02313824

UNSPSC Code:

41116107

PubChem Substance ID:

329830883

NACRES:

NA.24

grade

pharmaceutical primary standard

API family

perindopril

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

CC(C)(C)N.CCC[C@H](N[C@@H](C)C(=O)N1[C@H]2CCCC[C@H]2C[C@H]1C(O)=O)C(=O)OCC

InChI

1S/C19H32N2O5.C4H11N/c1-4-8-14(19(25)26-5-2)20-12(3)17(22)21-15-10-7-6-9-13(15)11-16(21)18(23)24;1-4(2,3)5/h12-16,20H,4-11H2,1-3H3,(H,23,24);5H2,1-3H3/t12-,13-,14-,15-,16-;/m0./s1

InChI key

IYNMDWMQHSMDDE-MHXJNQAMSA-N

Gene Information

human ... ACE(1636)

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Related Categories

Analytical Reference Standards

Pharmacopeia & Metrological Institute Standards

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Perindopril for stereochemical purity EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Perindopril erbumine is an angiotensin converting enzyme (ACE) inhibitor; antihypertensive; becomes hydrolyzed in vivo to the active diacid metabolite; unlike the other ACE inhibitors, inhibits tumor growth in hepatocellular carcinoma cells due to suppression of VEGF levels; also suppresses angiotensin II production in vitro. Long-term therapy with this agent has a beneficial effect on the cerebral circulation by improving cerebral perfusion reserve in patients with previous minor stroke.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

related product

Product No.

Description

Pricing

1510903

1510999

1510947

1510925

1510936

1510914

PHR1887

Perindopril erbumine, Pharmaceutical Secondary Standard; Certified Reference Material

BP1073

Perindopril erbumine, British Pharmacopoeia (BP) Reference Standard

PHR3078

Pictograms

GHS08

Signal Word

Warning

Hazard Statements

H361d

Precautionary Statements

P201 - P202 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Repr. 2

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Lot/Batch Number

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Applanation tonometry in mice: a novel noninvasive technique to assess pulse wave velocity and arterial stiffness.

Arthur J A Leloup et al.

Hypertension (Dallas, Tex. : 1979), 64(1), 195-200 (2014-04-23)

Arterial stiffening is the root cause of a range of cardiovascular complications, including myocardial infarction, left ventricular hypertrophy, stroke, renal failure, dementia, and death, and a hallmark of the aging process. The most important in vivo parameter of arterial stiffness

Inhibition of AAA in a rat model by treatment with ACEI perindopril.

Fei Xiong et al.

The Journal of surgical research, 189(1), 166-173 (2014-03-08)

The purpose of the present study was to evaluate the effect of a new angiotensin converting enzyme inhibitor perindopril on the formation of experimental abdominal aortic aneurysms (AAAs) in a rat model induced by intraluminal elastase infusion and extraluminal calcium

Follow-up of blood-pressure lowering and glucose control in type 2 diabetes.

Sophia Zoungas et al.

The New England journal of medicine, 371(15), 1392-1406 (2014-09-23)

In the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE) factorial trial, the combination of perindopril and indapamide reduced mortality among patients with type 2 diabetes, but intensive glucose control, targeting a glycated hemoglobin

Hepatic, intestinal, renal, and plasma hydrolysis of prodrugs in human, cynomolgus monkey, dog, and rat: implications for in vitro-in vivo extrapolation of clearance of prodrugs.

Haruka Nishimuta et al.

Drug metabolism and disposition: the biological fate of chemicals, 42(9), 1522-1531 (2014-07-06)

Hydrolysis plays an important role in metabolic activation of prodrugs. In the current study, species and in vitro system differences in hepatic and extrahepatic hydrolysis were investigated for 11 prodrugs. Ten prodrugs in the data set are predominantly hydrolyzed by

Clopidogrel bioactivation and risk of bleeding in patients cotreated with angiotensin-converting enzyme inhibitors after myocardial infarction: a proof-of-concept study.

K E Kristensen et al.

Clinical pharmacology and therapeutics, 96(6), 713-722 (2014-09-16)

Clopidogrel is an oral antiplatelet prodrug, the majority of which is hydrolyzed to an inactive metabolite by hepatic carboxylesterase 1 (CES1). Most angiotensin-converting enzyme inhibitors (ACEIs) are also metabolized by this enzyme. We examined the effects of ACEIs on clopidogrel

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