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Y0000040

Ciclopirox

Name: Ciclopirox
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone

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About This Item

Empirical Formula (Hill Notation):

C₁₂H₁₇NO₂

CAS Number:

29342-05-0

Molecular Weight:

207.27

MDL number:

MFCD00599441

UNSPSC Code:

41116107

NACRES:

NA.24

grade

pharmaceutical primary standard

API family

ciclopirox

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

ON1C(C2CCCCC2)=CC(C)=CC1=O

InChI

1S/C12H17NO2/c1-9-7-11(13(15)12(14)8-9)10-5-3-2-4-6-10/h7-8,10,15H,2-6H2,1H3

InChI key

SCKYRAXSEDYPSA-UHFFFAOYSA-N

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Related Categories

Analytical Reference Standards

Pharmacopeia & Metrological Institute Standards

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Ciclopirox EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

related product

Product No.

Description

Pricing

1134040

1134018

Ciclopirox, United States Pharmacopeia (USP) Reference Standard

1134084

1134029

PHR2854

Pictograms

GHS07

Signal Word

Warning

Hazard Statements

H302 + H312 + H332,H319

Precautionary Statements

P261 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2

WGK

WGK 3

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Lot/Batch Number

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Ciclopirox 1% shampoo for the treatment of seborrheic dermatitis.

Aditya K Gupta et al.

International journal of dermatology, 45(1), 66-69 (2006-01-24)

Seborrheic dermatitis is a chronic superficial fungal infection of the skin, particularly affecting sites rich in sebaceous glands. Although the precise etiology of seborrheic dermatitis is uncertain, yeasts of the genus Malassezia are known to play a causative role. Ciclopirox

Ciclopirox nail lacquer solution 8% in the 21st century.

A K Gupta et al.

Journal of the American Academy of Dermatology, 43(4 Suppl), S96-102 (2000-10-29)

Ciclopirox nail lacquer solution 8% has been shown to be effective in the treatment of dermatophyte onychomycosis of mild to moderate severity Other studies report the effectiveness of ciclopirox nail lacquer in onychomycosis caused by Candida sp and nondermatophyte molds.

Dermatopharmacology of ciclopirox nail lacquer topical solution 8% in the treatment of onychomycosis.

M Bohn et al.

Journal of the American Academy of Dermatology, 43(4 Suppl), S57-S69 (2000-10-29)

Ciclopirox is a synthetic hydroxypyridone antifungal agent. In contrast to the azoles, glucuronidation is the main metabolic pathway of ciclopirox; therefore interactions with drugs metabolized via the cytochrome P450 system are unlikely Ciclopirox is also distinct from the common systemic

Ciclopirox for the treatment of superficial fungal infections: a review.

Aditya K Gupta et al.

International journal of dermatology, 42 Suppl 1, 3-9 (2003-08-05)

Ciclopirox is a broad-spectrum antifungal agent that also exhibits anti-inflammatory and antibacterial activity. The lotion and cream formulations of ciclopirox are effective in many types of infection, including tinea corporis/cruris, tinea pedis, cutaneous candidiasis, pityriasis (tinea) versicolor, and seborrheic dermatitis.

Ciclopirox: recent nonclinical and clinical data relevant to its use as a topical antimycotic agent.

Alessandro Subissi et al.

Drugs, 70(16), 2133-2152 (2010-10-23)

Ciclopirox is a topical antimycotic agent belonging to the chemical class of hydroxypyridones and not related to azoles or any other class of antifungal agents. Its antimicrobial profile includes nearly all of the clinically relevant dermatophytes, yeasts and moulds, and

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