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T7891

Supelco

Thiochrome

analytical standard

Synonym(s):

2,7-Dimethylthiachromine-8-ethanol

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About This Item

Empirical Formula (Hill Notation):
C12H14N4OS
CAS Number:
92-35-3
Molecular Weight:
262.33
EC Number:
202-149-9
MDL number:
MFCD00010519
UNSPSC Code:
41116107
PubChem Substance ID:
24900483
NACRES:
NA.24

grade

analytical standard

Quality Level

100

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

SMILES string

Cc1ncc2CN3C(C)=C(CCO)SC3=Nc2n1

InChI

1S/C12H14N4OS/c1-7-10(3-4-17)18-12-15-11-9(6-16(7)12)5-13-8(2)14-11/h5,17H,3-4,6H2,1-2H3

InChI key

GTQXMAIXVFLYKF-UHFFFAOYSA-N

Related Categories

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Selective M4 muscarinic receptor enhancer of acetylcholine affinity.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number

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B Sebecić et al.
Die Nahrung, 30(5), 527-532 (1986-01-01)
A modified fluorometric method for the determination of thiamine in food is described. The procedure is simple, reproducible, does not demand costly outfit and chemicals and is not susceptible to interference. The recovery of added thiamine is good.
Zubair Anwar et al.
Journal of photochemistry and photobiology. B, Biology, 203, 111766-111766 (2020-01-14)
The photolysis of thiochrome (THC), an oxidation product of thiamine (vitamin B1) (THE), used for its fluorimetric assay, has been studied in the pH range 7.0-12.0. THC undergoes photooxidation to oxodihydrothiochrome (ODTHC) which is oxidized to a non-fluorescent compound (OP1)
Nathalie Mangel et al.
Journal of experimental botany, 68(13), 3351-3363 (2017-09-02)
Vitamin B1, which consists of the vitamers thiamin and its phosphorylated derivatives, is an essential micronutrient for all living organisms because it is required as a metabolic cofactor in several enzymatic reactions. Genetic diversity of vitamin B1 biosynthesis and accumulation
S Lazareno et al.
Molecular pharmacology, 65(1), 257-266 (2004-01-15)
Thiochrome (2,7-dimethyl-5H-thiachromine-8-ethanol), an oxidation product and metabolite of thiamine, has little effect on the equilibrium binding of l-[3H]N-methyl scopolamine ([3H]NMS) to the five human muscarinic receptor subtypes (M1-M5) at concentrations up to 0.3 mM. In contrast, it inhibits [3H]NMS dissociation
Amirah N Kamarudin et al.
Frontiers in plant science, 8, 1799-1799 (2017-11-02)
Thiamine, or vitamin B1 plays an indispensable role as a cofactor in crucial metabolic reactions including glycolysis, pentose phosphate pathway and the tricarboxylic acid cycle in all living organisms. Thiamine has been shown to play a role in plant adaptation
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