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T2695

Supelco

Tetrandrine

analytical standard, for drug analysis

Synonym(s):

(1β)-6,6′,7,12-Tetramethoxy-2,2′-dimethylberbaman

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About This Item

Empirical Formula (Hill Notation):
C38H42N2O6
CAS Number:
518-34-3
Molecular Weight:
622.75
MDL number:
MFCD08689909
UNSPSC Code:
41116107
PubChem Substance ID:
329826723
NACRES:
NA.24

grade

analytical standard, for drug analysis

Quality Level

100

Assay

≥90%

form

solid

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

SMILES string

COc1ccc2C[C@@H]3N(C)CCc4cc(OC)c(OC)c(Oc5cc6[C@H](Cc7ccc(Oc1c2)cc7)N(C)CCc6cc5OC)c34

InChI

1S/C38H42N2O6/c1-39-15-13-25-20-32(42-4)34-22-28(25)29(39)17-23-7-10-27(11-8-23)45-33-19-24(9-12-31(33)41-3)18-30-36-26(14-16-40(30)2)21-35(43-5)37(44-6)38(36)46-34/h7-12,19-22,29-30H,13-18H2,1-6H3/t29-,30-/m0/s1

InChI key

WVTKBKWTSCPRNU-KYJUHHDHSA-N

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General description

Tetrandrine (TET) is classified under the bisbenzylisoquinoline alkaloid family of compounds extracted from Stephania tetrandra S. Moore.

Application

Analgesic, antipyretic.
TET may be used as an analytical reference standard for the determination of TET in:
  • Blood samples by online multidimensional solid phase extraction liquid chromatography coupled to tandem mass spectrometry (MD-SPE-LC-MS/MS) equipped with electrospray ionization (ESI) source and multiple reaction monitoring (MRM) detection.
  • Rat plasma by ultra-high performance liquid chromatography (UHPLC) combined with MS/MS with MRM detection.
  • Qi-Fang-Xi-Bi-Granules used in Chinese medicine by reversed phase HPLC equipped with ultraviolet (UV) detector.
  • Fangji Huangqi Tang Chinese medicine by UHPLC coupled to triple quadrupole mass spectrometry (QqQ-MS) with MRM detection.

It may be used as an internal standard for the determination of hernandezine in:
  • Rat plasma and tissues by UHPLC-MS/MS with MRM detection.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H300

Hazard Classifications

Acute Tox. 2 Oral

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

监管及禁止进口产品

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Certificates of Analysis (COA)

Lot/Batch Number

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Determination of a novel anticancer AMPK activator hernandezine in rat plasma and tissues with a validated UHPLC-MS/MS method: Application to pharmacokinetics and tissue distribution study.
Song Y, et al.
Journal of Pharmaceutical and Biomedical Analysis, 141(8), 132-139 (2017)
Development and validation of an UHPLC-QqQ-MS technique for simultaneous determination of ten bioactive components in Fangji Huangqi Tang.
Wang X, et al.
Journal of Analytical Methods in Chemistry, 2016(8), 1328-1332 (2016)
C Y Kwan et al.
Life sciences, 68(7), 841-847 (2001-02-24)
The effects of tetrandrine (TET), a Ca2+ antagonist of bis-benzylisoquinoline alkaloid origin, on cultured single bovine pulmonary artery endothelial cells were examined using fluorescence ratio imaging and whole-cell attached patch-clamp techniques. Thapsigargin (TSG, 100 nM), a selective endoplasmic reticulum Ca2+-ATPase
Development and validation of an on-line multidimensional SPE-LC-MS/MS method for the quantitation of Tetrandrine in blood samples.
Caglar S, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 988, 25-32 (2015)
Gang Li et al.
BioMed research international, 2020, 2616024-2616024 (2020-05-29)
Oxidative damage is closely involved in the development of doxorubicin- (DOX-) induced cardiotoxicity. It has been reported that tetrandrine can prevent the development of cardiac hypertrophy by suppressing reactive oxygen species- (ROS-) dependent signaling pathways in mice. However, whether tetrandrine
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