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About This Item
Empirical Formula (Hill Notation):
C14H12O3S
CAS Number:
Molecular Weight:
260.31
UNSPSC Code:
41116107
NACRES:
NA.24
SMILES string
[s]1c(ccc1C(=O)c2ccccc2)C(C)C(=O)O
InChI
1S/C14H12O3S/c1-9(14(16)17)11-7-8-12(18-11)13(15)10-5-3-2-4-6-10/h2-9H,1H3,(H,16,17)
InChI key
GUHPRPJDBZHYCJ-UHFFFAOYSA-N
grade
pharmaceutical primary standard
API family
tiaprofenic acid
manufacturer/tradename
EDQM
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Application
Tiaprofenic acid EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
Other Notes
Sales restrictions may apply.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Repr. 2
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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R Buchbinder et al.
Journal of clinical epidemiology, 53(10), 1013-1019 (2000-10-12)
A case-control study was performed to describe the clinical course and identify risk factors predisposing to the development of tiaprofenic acid associated cystitis. Cases were identified from reports to the Australian Adverse Drug Reactions Advisory Committee and a two-year (1995-1996)
Klefah A K Musa et al.
The journal of physical chemistry. B, 113(32), 11306-11313 (2009-09-02)
The photodegradation of nonsteroid anti-inflammatory drugs suprofen, 2-[4-(2-thienoyl)phenyl]propionic acid, and tiaprofenic acid, 2-(5-benzoyl-2-thienyl)propanoic acid, is studied by means of density functional theory. Besides the redox properties of the neutral species, we report on absorption spectra and degradation pathways involving excitation
C Agapakis-Caussé et al.
Photochemistry and photobiology, 71(5), 499-505 (2000-05-20)
In order to determine whether or not tiaprofenic acid (TPA) could cause cellular DNA damage, human fibroblasts were irradiated in the presence of the drug and subsequently examined by means of the comet assay. This led to the observation that
A Lahoz et al.
Chemical research in toxicology, 14(11), 1486-1491 (2001-11-20)
Drug-induced photoallergy is an immune adverse reaction to the combined effect of drugs and light. From the mechanistic point of view, it first involves covalent binding of drug to protein resulting in the formation of a photoantigen. Hence, determination of
D L Scott et al.
Rheumatology (Oxford, England), 39(10), 1095-1101 (2000-10-18)
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used to treat osteoarthritis (OA), though their long-term efficacy is uncertain. We report a comparison of the symptomatic responses to therapy with tiaprofenic acid, indomethacin and placebo over 5 yr. A parallel-group, randomized, single-blind
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