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T0100000

Testosterone

European Pharmacopoeia (EP) Reference Standard

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Synonym(s):
17β-Hydroxy-3-oxo-4-androstene, 17β-Hydroxy-4-androsten-3-one, 4-Androsten-17β-ol-3-one, trans-Testosterone
Empirical Formula (Hill Notation):
C19H28O2
CAS Number:
58-22-0
Molecular Weight:
288.42
Beilstein:
1915399
EC Number:
200-370-5
MDL number:
MFCD00003654
UNSPSC Code:
41116107
PubChem Substance ID:
329826587
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

testosterone

manufacturer/tradename

EDQM

drug control

USDEA Schedule IIIN; regulated under CDSA - not available from Sigma-Aldrich Canada

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2O

InChI

1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1

InChI key

MUMGGOZAMZWBJJ-DYKIIFRCSA-N

Gene Information

human ... AR(367)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Testosterone EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Testosterone secreted by the testis is converted to dihydrotestosterone in the target tissues where it appears to mediate many of the biological actions of testosterone. Androgens direct the development of the male phenotype during embryogenesis and at puberty.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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Y0001317

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Testosterone enantate impurity H, European Pharmacopoeia (EP) Reference Standard

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Testosterone propionate for system suitability, European Pharmacopoeia (EP) Reference Standard

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1646010

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BP319

Testosterone decanoate, British Pharmacopoeia (BP) Reference Standard

BP321

Testosterone isocaproate, British Pharmacopoeia (BP) Reference Standard

BP1076

Testosterone, British Pharmacopoeia (BP) Reference Standard

1647012

Testosterone Cypionate Related Compound A, United States Pharmacopeia (USP) Reference Standard

PHR2026

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PHR2027

Testosterone, Pharmaceutical Secondary Standard; Certified Reference Material

1647023

Testosterone Cypionate Related Compound B, United States Pharmacopeia (USP) Reference Standard

Y0002163

Testosterone for ID and assay, CRS, European Pharmacopoeia (EP) Reference Standard

Y0002174

Testosterone for system suitability A, CRS, European Pharmacopoeia (EP) Reference Standard

Y0002145

Testosterone impurity I, CRS, European Pharmacopoeia (EP) Reference Standard

PHR9196

5α-Androstan-17β-ol-3-one, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

Signal Word

Danger

Hazard Statements

H302,H351,H360FD,H400

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Carc. 2 - Repr. 1B

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

监管及禁止进口产品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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David J Handelsman
The Journal of clinical endocrinology and metabolism, 91(5), 1646-1653 (2006-02-16)
The objective of the study was to review the rationale underlying the banning of human chorionic gonadotropin (hCG) and estrogen blockers (antiestrogens, specific estrogen receptor modulators, aromatase inhibitors) in sports for male and female athletes in the light of gender
Y Zimmerman et al.
Human reproduction update, 20(1), 76-105 (2013-10-02)
BACKGROUND; Combined oral contraceptives (COCs) reduce levels of androgen, especially testosterone (T), by inhibiting ovarian and adrenal androgen synthesis and by increasing levels of sex hormone-binding globulin (SHBG). Although this suppressive effect has been investigated by numerous studies over many
Marie Sinclair et al.
Transplantation, 98(7), 788-792 (2014-06-12)
Low pretransplant serum testosterone has recently been associated with increased mortality in men awaiting liver transplantation, but the potential impact on rejection has not yet been investigated. Pretransplantation serum testosterone, SHBG, and other variables were collected on 190 consecutive men
Andrea C Lo et al.
International journal of radiation oncology, biology, physics, 88(1), 87-93 (2013-12-18)
To determine (1) the prognostic utility of prostate-specific antigen (PSA) concentration at 45 to 60 months (48mPSA) after low-dose-rate prostate brachytherapy (LDR-PB); (2) the predictors of 48mPSA; and (3) the prognostic utility of directional trends between PSA levels at 24
James R Bell et al.
American journal of physiology. Heart and circulatory physiology, 306(9), H1265-H1274 (2014-03-13)
Estrogen in females is conventionally considered a cardioprotective influence, but a role for estrogen in male cardioprotection has yet to be defined. Estrogen biosynthesis from testosterone is regulated by aromatase. Aromatase has recently been shown to be expressed in the
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