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SMB01363

Sigma-Aldrich

5α-Tetrahydrocortisol

≥95% (HPLC)

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Synonym(s):
5α-Pregnane-3α,11β,17α,21-tetrol-20-one, α-THF, 5 alpha-Tetrahydrocortisol, ATHF, Allo-3a-tetrahydrocortisol, 3α,11β,17α,21-Tetrahydroxy-5α-pregnan-20-one, 3α,5α-Tetrahydrocortisol, Allopregnane-3α,11β,17α,21-tetrol-20-one, Allotetrahydrocortisol, Kendall’s compound C, Reichstein’s substance C
Empirical Formula (Hill Notation):
C21H34O5
CAS Number:
302-91-0
Molecular Weight:
366.49
MDL number:
MFCD00003670
UNSPSC Code:
51111800
NACRES:
NA.21

Quality Level

200

Assay

≥95% (HPLC)

form

solid

storage temp.

2-8°C

SMILES string

C[C@@]12CC[C@H](O)C[C@H]1CC[C@@H]3[C@H]4CC[C@@](O)(C(=O)CO)[C@@]4(C)C[C@@H](O)[C@@H]23

InChI

1S/C21H34O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h12-16,18,22-24,26H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18+,19-,20-,21-/m0/s1

InChI key

AODPIQQILQLWGS-FDSHTENPSA-N

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General description

5α-Tetrahydrocortisol, also known as Allo-3a-tetrahydro cortisol (ATHC), a synthetic corticosteroid hormone derived from cortisol, is widely employed in biochemical and proteomics research. It is a metabolite of cortisol, a natural glucocorticoid that is used to treat various immune, inflammatory, and neoplastic conditions. In the context of medical diagnosis, a higher ratio of specific urinary metabolites can indicate the presence of Apparent Mineralocorticoid Excess (AME) syndrome, a rare form of hypertension linked to abnormalities in cortisol metabolism.

Application

5α-Tetrahydrocortisol finds application as a Biomarker in AME studies pertaining to Cortisol metabolism research

Features and Benefits

  • Can be used in Metabolomics and Biochemical research
  • High-quality compound suitable for multiple research applications

Other Notes

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Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H317,H413

Hazard Classifications

Aquatic Chronic 4 - Skin Sens. 1

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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