All Photos(1)
Synonym(s):
5β-Pregnane-11β,17α,21-triol-3,20-dione, 11β,17,21-Trihydroxy-5β-pregnane-3,20-dione, 11β,17α,21-Trihydroxy-5β-pregnane-3,20-dione, 5β-Dihydrocortisol
Empirical Formula (Hill Notation):
C21H32O5
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Quality Level
Assay
≥95% (HPLC)
form
solid
storage temp.
2-8°C
InChI
1S/C21H32O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h12,14-16,18,22,24,26H,3-11H2,1-2H3/t12-,14+,15+,16+,18-,19+,20+,21+/m1/s1
InChI key
ACSFOIGNUQUIGE-AIPUTVCKSA-N
General description
5β-Dihydrocortisol is the product of the enzyme steroid 5-beta-reductase, which catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone, testosterone, aldosterone, corticosterone, and cortisol to 5-beta-reduced metabolites. 5β-Dihydrocortisol has shown to potentiate the action of topically applied dexamethasone in raising the intraocular pressure in young rabbits.
Application
Metabolomics research
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Repr. 1A - STOT RE 2
WGK
WGK 3
Regulatory Information
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A L Southren et al.
Investigative ophthalmology & visual science, 26(3), 393-395 (1985-03-01)
5 beta-dihydrocortisol potentiates the action of topically applied dexamethasone in raising the intraocular pressure (IOP) in young rabbits. Dexamethasone (0.06%) plus 5 beta-dihydrocortisol (0.1 and 1.0%) elevated the IOP 7-10 mmHg within 18 days of treatment. By contrast, 0.06% dexamethasone
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