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Safety Information

S7920

Sigma-Aldrich

Sodium fluoride

BioXtra, ≥99%

Synonym(s):

NaF, Natrium fluoride, Sodium monoflouride

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About This Item

Linear Formula:
NaF
CAS Number:
7681-49-4
Molecular Weight:
41.99
EC Number:
231-667-8
MDL number:
MFCD00003524
UNSPSC Code:
12352302
PubChem Substance ID:
24899770
NACRES:
NA.25

vapor pressure

1.4 mmHg ( 0 °C)

Quality Level

200

product line

BioXtra

Assay

≥99%

impurities

≤0.0005% Phosphorus (P)
≤0.1% Insoluble matter

mp

993 °C (lit.)

solubility

H2O: 1 M, clear, colorless

anion traces

chloride (Cl-): ≤0.005%
sulfate (SO42-): ≤0.03%

cation traces

Al: ≤0.001%
Ca: ≤0.0005%
Cu: ≤0.0005%
Fe: ≤0.003%
K: ≤0.02%
Mg: ≤0.0005%
NH4+: ≤0.1%
Pb: ≤0.001%
Zn: ≤0.0005%

SMILES string

[F-].[Na+]

InChI

1S/FH.Na/h1H;/q;+1/p-1

InChI key

PUZPDOWCWNUUKD-UHFFFAOYSA-M

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Application

Sodium fluoride has been used:
  • as a source of fluoride ions, to analyse its impact on spermatogenesis and capacitation in vitro
  • as an additive in the extraction buffer for the isolation of nuclei, cytoplasmic and nuclear proteins
  • as a component of lysis buffer for the lysis of human ovarian adenocarcinoma OVCAR3 cells

Biochem/physiol Actions

Sodium fluoride (NaF) prevents dental caries, by catalysing the diffusion of calcium and phosphate and remineralizes the lesions. Fluoride affects spermatogenesis and capacitation process in the female reproductive tract. Fluoride induces oxidative stress, DNA damage in ovary ultimately affects the development of oocytes. Fluoride supplementation enhances bone mineral density. 18F-NaF is a radiotracer used in positron emission tomography (PET) to identify atherosclerotic lesions and other cardiac plaques.

Other Notes

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Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301,H315,H319

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2

Supplementary Hazards

EUH032

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

危险化学品

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Toxicological Profile for Fluorides, Hydrogen Fluoride, and Fluorine (Update) (2011)
Dental caries
Selwitz RH, et al.
Lancet, 369(9555), 51-59 (2007)
Mangiferin induces apoptosis in human ovarian adenocarcinoma OVCAR3 cells via the regulation of Notch3
Zou B, et al.
Oncology Reports, 38(3), 1431-1441 (2017)
Effects of treatment with fluoride on bone mineral density and fracture risk-a meta-analysis
Vestergaard P, et al.
Osteoporosis International : A Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 19(3), 257-268 (2008)
Fluoride-induced oxidative stress and apoptosis are involved in the reducing of oocytes development potential in mice
Wang HW, et al.
Chemosphere, 186, 911-918 (2017)
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