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Merck
CN

S6387

Sulfadiazine sodium salt

≥98% (HPLC)

Synonym(s):

4-Amino-N-(2-pyrimidinyl)benzenesulfonamide sodium salt, SPS Agar Supplement

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About This Item

Empirical Formula (Hill Notation):
C10H9N4NaO2S
CAS Number:
547-32-0
Molecular Weight:
272.26
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329824562
EC Number:
208-919-0
Beilstein/REAXYS Number:
4068213
MDL number:
MFCD00067333

Key Documents

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Product Name

Sulfadiazine sodium salt, ≥98% (HPLC)

InChI key

JLDCNMJPBBKAHH-UHFFFAOYSA-N

InChI

1S/C10H9N4O2S.Na/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10;/h1-7H,11H2;/q-1;+1

SMILES string

Nc1ccc(cc1)S(=O)(=O)N([Na])c2ncccn2

grade

analytical standard

assay

≥98% (HPLC)

form

crystalline powder

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

Quality Level

100

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Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Sulfadiazine may be used as an internal standard for the determination of sulfapyridine in biological samples using high-performance liquid chromatography technique.

General description

Sulfadiazine sodium salt is a broad-spectrum antibiotic belonging to the class of sulfonamides commonly used against gram-postive and gram-negative microorganisms in humans and veterinary medication. Its mode of action involves inhibiting the multiplication of bacteria as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle.

pictograms

Exclamation markEnvironment
GHS07,GHS09

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000430824
0000430824
0000359049
0000359048
0000252608

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Jia-Hui Cheng et al.
International immunopharmacology, 82, 106302-106302 (2020-02-23)
Toxoplasma gondii (T. gondii) is a known neurotropic protozoan that remains in the central nervous system and induces neuropsychiatric diseases in intermediate hosts. Arctigenin (AG) is one of the major bioactive lignans of the fruit Arctium lappa L. and has
Yu-Nan Lu et al.
International immunopharmacology, 84, 106539-106539 (2020-05-04)
Toxoplasmosis is a parasitic zoonosis with the highest incidence in humans. Severe lesions due to acute toxoplasmosis have been recorded in the visceral organs including the liver, where hepatocytes and Kupffer cells are important innate immune cells. Arctigenin (AG) is
High-performance liquid chromatographic method for determination of sulfapyridine in human saliva using post-column, in-line derivatization with fluorescamine
Sista.S.H, et al.
Journal of Chromatography. B, Biomedical Applications, 273(2), 103-106 (1983)
Drugs: Synonyms and Properties (2017)
Eco-toxic effects of sulfadiazine sodium, sulfamonomethoxine sodium and enrofloxacin on wheat, Chinese cabbage and tomato
Ecotoxicology (London, England), 18(7), 878-885 (2009)
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