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S1429

Sigma-Aldrich

Sodium acetate

meets USP testing specifications, anhydrous

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Synonym(s):
Acetic acid sodium salt
Linear Formula:
CH3COONa
CAS Number:
127-09-3
Molecular Weight:
82.03
Beilstein:
3595639
EC Number:
204-823-8
MDL number:
MFCD00012459
UNSPSC Code:
12352300
eCl@ss:
39021906
PubChem Substance ID:
24899479
NACRES:
NA.21

grade

anhydrous

Quality Level

200

Agency

USP/NF
meets USP testing specifications

Assay

99-101% dry basis

form

solid

autoignition temp.

1112 °F

pH

8.5-9.9 (25 °C, 246 g/L)

pKa 

4.76 (acetic acid)

mp

>300 °C (dec.) (lit.)

solubility

soluble 246 g/L at 20 °C (completely)

application(s)

pharmaceutical (small molecule)

SMILES string

[Na+].CC([O-])=O

InChI

1S/C2H4O2.Na/c1-2(3)4;/h1H3,(H,3,4);/q;+1/p-1

InChI key

VMHLLURERBWHNL-UHFFFAOYSA-M

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General description

Sodium acetate (SA) exhibits antimicrobial and antioxidant properties. It is used as an exchange-fluid buffer in hemodialysis. SA acts as an a alkalinizing agent and its continuous intravenous (IV) infusion causes salicylate intoxication.

Application

Sodium acetate (SA) has been used to increase hepatic acetyl- coenzyme A in caloric restricted rats.

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Sodium Acetate as an Alkalinizing Agent for Salicylate Intoxication: A Case Report
Groke SF, et al.
Journal of Clinical Toxicology (2015)
Enhancement of in-vitro human interleukin-1 production by sodium acetate
Bingel M, et al.
Lancet, 329(8523), 14-16 (1987)
Antimicrobial and antioxidant effects of sodium acetate, sodium lactate, and sodium citrate in refrigerated sliced salmon
Sallam KI, et al.
Food Control, 18(5), 566-575 (2007)
Mechanisms by which a very-low-calorie diet reverses hyperglycemia in a rat model of type 2 diabetes
Perry RJ, et al.
Cell Metabolism, 27(1), 210-217 (2018)
Graham R Scott et al.
Molecular biology and evolution, 32(8), 1962-1976 (2015-04-09)
At high-altitude, small mammals are faced with the energetic challenge of sustaining thermogenesis and aerobic exercise in spite of the reduced O2 availability. Under conditions of hypoxic cold stress, metabolic demands of shivering thermogenesis and locomotion may require enhancements in
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