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S0750000

Sodium cromoglicate

European Pharmacopoeia (EP) Reference Standard

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Synonym(s):
Cromolyn sodium salt, Cromoglycate, Cromoglycic acid
Linear Formula:
C23H14O11Na2
CAS Number:
15826-37-6
Molecular Weight:
512.33
MDL number:
MFCD00057744
UNSPSC Code:
41116107
PubChem Substance ID:
329824437
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

sodium cromoglicate

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

[Na].OC(COc1cccc2OC(=CC(=O)c12)C(O)=O)COc3cccc4OC(=CC(=O)c34)C(O)=O

InChI

1S/C23H16O11.Na.H/c24-11(9-31-14-3-1-5-16-20(14)12(25)7-18(33-16)22(27)28)10-32-15-4-2-6-17-21(15)13(26)8-19(34-17)23(29)30;;/h1-8,11,24H,9-10H2,(H,27,28)(H,29,30);;

InChI key

UXMUBZWVLQEMRB-UHFFFAOYSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Sodium cromoglicate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Cromolyn blocks the release of histamine and other pro-inflammatory mediators from mast cells.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

related product

Product No.
Description
Pricing

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Precautionary Statements

P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Development and validation of impurity-profiling UPLC method for the determination of sodium cromoglicate and tetryzoline hydrochloride: Application on rabbit aqueous humor.
Lotfy HM, et al.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 1006, 121-129 (2015)
Validated RP-HPLC method for estimation of sodium cromoglycate in human plasma.
Sowjanya P.
International Journal of Pharmaceutical Research and Development, 5, 112-120 (2013)
Effects of sodium cromoglycate on cytokine production following antigen stimulation of a passively sensitized human lung model.
Matsuo N, et al.
Annals of Allergy, Asthma & Immunology, 84(1), 72-78 (2000)
Eyal Zur
International journal of pharmaceutical compounding, 16(5), 386-393 (2012-10-18)
Sodium cromoglicate (cromolyn sodium) is a very well-known medicine that has been used for many years for various allergic conditions. The topical use of this medicine is less known, and there are no commercial medicines of cream, gel, or lotion
Lindsey L Kennedy et al.
Laboratory investigation; a journal of technical methods and pathology, 94(12), 1406-1418 (2014-11-05)
Cholangiopathies are characterized by dysregulation of the balance between biliary growth and loss. We have shown that histamine (HA) stimulates biliary growth via autocrine mechanisms. To evaluate the paracrine effects of mast cell (MC) stabilization on biliary proliferation, sham or
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