RDD043
Acetylcholine chloride
≥99% (TLC), free-flowing, Redi-Dri™
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Synonym(s):
2-Acetoxyethyltrimethylammonium chloride, Trimethyl(2-acetoxyethyl)ammonium chloride, ACh
Linear Formula:
(CH3)3N+CH2CH2OCOCH3Cl-
CAS Number:
Molecular Weight:
181.66
Beilstein:
3571875
MDL number:
UNSPSC Code:
51151535
NACRES:
NA.25
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product line
Redi-Dri™
Quality Level
Assay
≥99% (TLC)
quality
free-flowing
mp
146-150 °C (lit.)
solubility
H2O: 100 mg/mL
SMILES string
[Cl-].CC(=O)OCC[N+](C)(C)C
InChI
1S/C7H16NO2.ClH/c1-7(9)10-6-5-8(2,3)4;/h5-6H2,1-4H3;1H/q+1;/p-1
InChI key
JUGOREOARAHOCO-UHFFFAOYSA-M
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General description
Acetylcholine Chloride, the chloride salt of acetylcholine, is a synthetic amino alcohol with cholinergic properties, making it a vital component in biochemical and neurotransmission studies. It replicates the effects of the endogenous acetylcholine compound, which plays a significant role in the immune system, inflammation, and allergy research. Acetylcholine chloride acts as a cholinergic neurotransmitter, binding to nicotinic and muscarinic acetylcholine receptors, facilitating the opening of calcium channels.Furthermore, Acetylcholine chloride (ACh chloride) functions as a potent cholinergic agonist, influencing the activity of dopaminergic (DAergic) neurons by stimulating nicotinic acetylcholine receptors (nAChRs). This feature is particularly relevant in studies related to the immune system and inflammation. Additionally, it demonstrates the capacity to inhibit the aggregation of p53 mutant peptide in vitro, which contributes to the exploration of biochemical and allergy research.
Application
Acetylcholine chloride has been used:
- as an agent to trigger sudomotor axon reflex response during autonomic test
- to induce contraction amplitude of pyloric circular smooth muscle strip (PCSMS) in rats
- as a substrate for acetylcholinesterase
- to stimulate after discharge in Aplysia bag cell neurons
Biochem/physiol Actions
Acetylcholine chloride, injected at 20 mg/kg body weight, reduces mortality and plasma proinflammatory cytokines in mice with experimentally-induced sepsis . The cholinergic anti-inflammatory mechanism is probably mediated by interaction of acetylcholine with α7n cholinoreceptor on monocytes, macrophages, and neutrophils, which decreases the levels of proinflammatory cytokines such as TNF-α, IL-1β, and IL-6.
Features and Benefits
- Redi-Dri™ format for Improved Efficiency and Time Savings
- Can be used in Metabolomics and Biochemical research
- High-quality compound suitable for multiple research applications
Caution
Very hygroscopic
Other Notes
For additional information on our range of Biochemicals, please complete this form.
Legal Information
Redi-Dri is a trademark of Sigma-Aldrich Co. LLC
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Certificates of Analysis (COA)
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Find documentation for the products that you have recently purchased in the Document Library.
Acetylcholine Chloride: Physical Profile
Profiles of Drug Substances, Excipients, and Related Methodology, 31, 1-19 (2005)
Diarrhoea of famine and malnutrition--investigations using a rat model. 2--Ileal hypersecretion induced by starvation.
Young A and Levin RJ
Gut, 31(2), 162-169 (1990)
Stability of acetylcholine chloride solution in autonomic testing
Sletten DM, et al.
Journal of the Neurological Sciences, 234(1-2), 1-3 (2005)
Effect of aurantii fructus immaturus flavonoid on the contraction of isolated gastric smooth muscle strips in rats
Wu Z, et al.
Evidence-Based Complementary and Alternative Medicine : ECAM, 2016 (2016)
Acetylcholine-evoked afterdischarge in Aplysia bag cell neurons
White SH and Magoski NS
American Journal of Physiology. Heart and Circulatory Physiology (2012)
Articles
Redi-Dri™ prevents hygroscopic powders, such as inorganic salts, from absorbing moisture and forming clumps, leaving the salts free-flowing every time.
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