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R2751

Sigma-Aldrich

Ruthenium Red

Powder

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Synonym(s):
Ammoniated ruthenium oxychloride
Linear Formula:
[(NH3)5RuORu(NH3)4ORu(NH3)5]Cl6
CAS Number:
11103-72-3
Molecular Weight:
786.35
Colour Index Number:
77800
MDL number:
MFCD00011479
UNSPSC Code:
12171500
PubChem Substance ID:
24278675
NACRES:
NA.47

Quality Level

200

Assay

34-39% (RUTHENIUM, ICP)

form

powder

solubility

water: 10 mg/mL

εmax

≥150 at 533-534 nm

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

N.N.N.N.N.N.N.N.N.N.N.N.N.N.[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Ru++]O[Ru++]O[Ru++]

InChI

1S/6ClH.14H3N.2O.3Ru/h6*1H;14*1H3;;;;;/q;;;;;;;;;;;;;;;;;;;;;;3*+2/p-6

InChI key

ZXYSDUPLHOJIOR-UHFFFAOYSA-H

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General description

Ruthenium Red is a hexavalent polysaccharide stain. It inhibits mitochondrial Ca2+ uniporter. It is a capsaicin antagonist and blocks vanilloid receptor-1 (VR-1)-coupled ion channels.

Application

Ruthenium Red has been used for microscopic characterization of cotton tip morphology. It has also been used as a TRPV2 channel blocker.
Inhibits mitochondrial Ca2+ uniporter; capsaicin antagonist; blocks VR1 vanilloid receptor-coupled ion channels.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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TRPC1/TRPC3 channels mediate lysophosphatidylcholine-induced apoptosis in cultured human coronary artery smooth muscles cells
Yuan Wang
Oncotarget, 7(32) (2016)
Identification of an Aspartic Residue in the P-loop of the Vanilloid Receptor That Modulates Pore Properties*
Carolina Garcia-MArtinez
The Journal of Biological Chemistry (2000)
Ruthenium red, inhibitor of mitochondrial Ca2+ uniporter, inhibits curcumin-induced apoptosis via the prevention of intracellular Ca2+ depletion and cytochrome c release
Jae Hoon Bae
Biochemical and Biophysical Research Communications, 303 (2003)
George Goodwin et al.
Neuroscience, 429, 10-22 (2019-12-25)
Radiating pain is a significant feature of chronic musculoskeletal pain conditions such as radiculopathies, repetitive motion disorders and whiplash associated disorders. It is reported to be caused by the development of mechanically-sensitive ectopic receptive fields along intact nociceptor axons at
Cotton fiber tips have diverse morphologies and show evidence of apical cell wall synthesis
Michael R. Stiff and Candace H. Haigler
Scientific Reports (2016)
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