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R0150000

Ranitidine hydrochloride

Name: Ranitidine hydrochloride
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

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About This Item

Empirical Formula (Hill Notation):

C₁₃H₂₂N₄O₃S · HCl

CAS Number:

66357-59-3

Molecular Weight:

350.86

MDL number:

MFCD00069339

UNSPSC Code:

41116107

PubChem Substance ID:

329823974

NACRES:

NA.24

grade

pharmaceutical primary standard

API family

ranitidine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

Cl[H].CN\C(NCCSCc1ccc(CN(C)C)o1)=C\[N+]([O-])=O

InChI

1S/C13H22N4O3S.ClH/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3;/h4-5,9,14-15H,6-8,10H2,1-3H3;1H/b13-9-;

InChI key

GGWBHVILAJZWKJ-CHHCPSLASA-N

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Analytical Reference Standards

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Ranitidine hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

H₂ histamine receptor antagonist; anti-ulcer agent.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

related product

Product No.

Description

Pricing

1598405

Ranitidine hydrochloride, United States Pharmacopeia (USP) Reference Standard

1598507

1598700

1598609

PHR1774

PHR1773

PHR1775

BP471

Ranitidine hydrochloride, British Pharmacopoeia (BP) Reference Standard

PHR2180

Ranitidine Impurity I, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2181

Ranitidine Impurity J, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2179

Ranitidine Impurity H, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2182

Ranitidine Impurity K, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2175

Ranitidine Impurity D, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2177

Ranitidine Impurity F

PHR2178

Ranitidine Impurity G, Pharmaceutical Secondary Standard; Certified Reference Material

Pictograms

GHS08,GHS07

Signal Word

Danger

Hazard Statements

H315,H317,H319,H334,H335

Precautionary Statements

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Target Organs

Respiratory system

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Signal transduction mechanism of biased ligands at histamine H2 receptors.

Natalia Alonso et al.

The Biochemical journal, 459(1), 117-126 (2014-01-15)

7TMRs (seven-transmembrane receptors) exist as conformational collections in which different conformations would lead to differential downstream behaviours such as receptor phosphorylation, G-protein activation and receptor internalization. In this context, a ligand may cause differential activation of some, but not all

[The development of hemorrhagic vasculitis (Schönlein-Henoch disease) in a patient with a chronic stomach ulcer against a background of Sostril (ranitidine hydrochloride) therapy].

E N Glazunov et al.

Vestnik khirurgii imeni I. I. Grekova, 152(1-2), 102-103 (1994-01-01)

Chromatographic methods for determining the identity, strength and purity of ranitidine hydrochloride both in the drug substance and its dosage forms--an exercise in method selection, development, definition and validation.

M B Evans et al.

Journal of pharmaceutical and biomedical analysis, 7(1), 1-22 (1989-01-01)

The selection, development, definition and validation of selective stability-indicating procedures for high-performance liquid chromatographic and thin-layer chromatographic analyses of ranitidine hydrochloride are described. The procedures used in conjunction can be applied to the quality assurance and stability assessments of both

Ranitidine hydrochloride.

T S Gaginella et al.

Drug intelligence & clinical pharmacy, 17(12), 873-885 (1983-12-01)

Ranitidine is a selective, competitive histamine H2-receptor antagonist recently approved by the Food and Drug Administration for use in the short-term treatment of active duodenal ulcers and gastric hypersecretory conditions. Ranitidine is four to ten times more potent than cimetidine

Question 1: does the use of ranitidine increase the risk of NEC in preterm infants?

Manigandan Chandrasekaran et al.

Archives of disease in childhood, 99(4), 390-392 (2014-03-15)

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