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PHR2438

Supelco

Chloroquine Related Compound A

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):
4,7-Dichloroquinoline
Empirical Formula (Hill Notation):
C9H5Cl2N
CAS Number:
86-98-6
Molecular Weight:
198.05
Beilstein:
125359
MDL number:
MFCD00006774
UNSPSC Code:
41116107
NACRES:
NA.24

biological source

synthetic

Quality Level

300

grade

certified reference material
pharmaceutical secondary standard

Agency

BP
EP
USP
traceable to USP 1118328

vapor pressure

0.0000811 kPa ( 25 °C)

API family

chloroquine

form

crystalline

packaging

pkg of 50 mg

color

white to brown

pH

3.86 (24.9 °C)

bp

298.4 °F (148°C)

mp

81-83 °C (lit.)

solubility

water: slightly soluble 0.037 g/L at 25 °C
ethanol: freely soluble
ether: freely soluble

density

1.31 g/cm3 at 20 °C (971.4 hPa)

application(s)

pharmaceutical

storage temp.

2-30°C

SMILES string

Clc1ccc2c(Cl)ccnc2c1

InChI

1S/C9H5Cl2N/c10-6-1-2-7-8(11)3-4-12-9(7)5-6/h1-5H

InChI key

HXEWMTXDBOQQKO-UHFFFAOYSA-N

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General description

Chloroquine Related Compound A is an impurity of chloroquine, a 9-aminoquinoline drug that effectively inhibits viral infections in humans.
Chloroquine Related Compound A is an impurity of chloroquine, which is a 9-aminoquinoline drug that effectively inhibits viral infections in humans.

Application

Chloroquine Related Compound A can be used as a pharmaceutical primary standard for the determination of the analyte in pharmaceutical formulations by liquid chromatography (LC) technique.
Chloroquine Related Compound A can be used as a pharmaceutical secondary standard for the determination of the analyte in pharmaceutical formulations by liquid chromatography (LC) technique.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC4608 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

related product

Product No.
Description
Pricing

PHR1258

Chloroquine phosphate, Pharmaceutical Secondary Standard; Certified Reference Material

C1650000

Chloroquine sulfate, European Pharmacopoeia (EP) Reference Standard

1118328

Chloroquine Related Compound A, United States Pharmacopeia (USP) Reference Standard

1118361

Chloroquine Related Compound E, United States Pharmacopeia (USP) Reference Standard

1118350

Chloroquine Related Compound D, United States Pharmacopeia (USP) Reference Standard

1118394

Chloroquine Related Compound G, United States Pharmacopeia (USP) Reference Standard

1118000

Chloroquine phosphate, United States Pharmacopeia (USP) Reference Standard

PHR2933

Chloroquine Related Compound G, Pharmaceutical Secondary Standard; Certified Reference Material, certified reference material

Pictograms

Exclamation markEnvironment
GHS07,GHS09

Signal Word

Warning

Hazard Statements

H315,H317,H319,H411

Hazard Classifications

Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Chloroquine is a potent inhibitor of SARS coronavirus infection and spread
Vincent MJ, et al.
Virology Journal, 2(1), 1-10 (2005)
Chloroquine Phosphate USP Monograph
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 39(3), 959-959 (2020)

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