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PHR1975

Supelco

Dextromethorphan Impurity C

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

(9α,13α,14α)-3-Methoxy-17-methylmorphinan-10-one, 10-Keto dextromethorphan

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About This Item

Empirical Formula (Hill Notation):
C18H23NO2
CAS Number:
57969-05-8
Molecular Weight:
285.38
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to USP 1181040

CofA

current certificate can be downloaded

packaging

pkg of 30 mg

application(s)

pharmaceutical

format

neat

storage temp.

2-30°C

InChI

1S/C18H23NO2/c1-19-10-9-18-8-4-3-5-14(18)16(19)17(20)13-7-6-12(21-2)11-15(13)18/h6-7,11,14,16H,3-5,8-10H2,1-2H3/t14-,16-,18+/m1/s1

InChI key

UOCRGKKCNCIQCZ-KYJSFNMBSA-N

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General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Application


  • Pharmacokinetic Study of Alpha-Hydroxytriazolam: Research involving the urinary excretion of alpha-hydroxytriazolam after a single dose of Halcion provides insights into the metabolic pathways and elimination characteristics of this benzodiazepine derivative. Using α-Hydroxytriazolam-d₄ as an internal standard in mass spectrometry enhances the accuracy of such studies, which is critical for understanding the drug′s behavior in the human body and for developing therapeutic guidelines (Lin et al., 2005).

  • Confirmation of Urinary Benzodiazepine Metabolites: A study that utilizes gas chromatography-mass spectrometry (GC-MS) to confirm the presence of urinary benzodiazepine metabolites, including α-Hydroxytriazolam, emphasizes the role of α-Hydroxytriazolam-d₄ as a vital analytical standard. This research aids in forensic toxicology and clinical diagnostics by providing robust methodologies for the detection and quantification of benzodiazepines in biological samples (Meatherall, 1994).

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB3994 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301,H336

Hazard Classifications

Acute Tox. 3 Oral - STOT SE 3

Target Organs

Central nervous system

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
LRAD5348
LRAD2789
LRAC8571
LRAB3994
LRAC5707

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