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PHR1919

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Chlorzoxazone

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):
Chlorzoxazone, CLZ, 5-Chloro-2(3H)-benzoxazolone, 5-Chloro-2-hydroxybenzoxazole
Empirical Formula (Hill Notation):
C7H4ClNO2
CAS Number:
95-25-0
Molecular Weight:
169.57
EC Number:
222-649-0
MDL number:
MFCD00005717
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to USP 1130505

API family

chlorzoxazone

CofA

current certificate can be downloaded

packaging

pkg of 500 mg

mp

191-192 °C (lit.)

application(s)

pharmaceutical

format

neat

storage temp.

2-30°C

SMILES string

Clc1ccc2OC(=O)Nc2c1

InChI

1S/C7H4ClNO2/c8-4-1-2-6-5(3-4)9-7(10)11-6/h1-3H,(H,9,10)

InChI key

TZFWDZFKRBELIQ-UHFFFAOYSA-N

Gene Information

human ... KCNN4(3783)

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General description

Chlorzoxazone is a centrally active muscle relaxant used to treat painful muscle spasms linked to musculoskeletal disorders, such as fibrositis, bursitis, myositis, spondylitis, etc.
Pharmaceutical secondary standard for application in quality control. Provides pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Chlorzoxazone may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography technique, spectrophotometry and fluorescence spectroscopy.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Chlorzoxazone is a skeletal muscle relaxant.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB0913 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H315,H319,H335

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Development and validation of spectrophotometric methods for simultaneous estimation of tramadol hydrochloride and chlorzoxazone in tablet dosage form
Puranik M, et al.
Indian Journal of Pharmaceutical Sciences, 68(6), 737-737 (2006)
Simultaneous determination of aceclofenac, paracetamol, and chlorzoxazone by RP-HPLC in pharmaceutical dosage form
Shaikh KA and Devkhile AB
Journal of Chromatographic Science, 46(7), 649-652 (2008)
Analytical Profiles of Drug Substances, 16(7), 119-144 (1987)
Second derivative synchronous fluorescence spectroscopy for the simultaneous determination of chlorzoxazone and ibuprofen in pharmaceutical preparations and biological fluids
El-Enany N, et al.
International Journal of Biomedical Science : IJBS, 5(2), 136-136 (2009)

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