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PHR1892

Supelco

Voriconazole

Pharmaceutical Secondary Standard: Certified Reference Material

Synonym(s):

Voriconazole, 2R,3S-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol, UK-109496

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25 MG
¥1,319.86
200 MG
¥3,601.49
500 MG
¥6,917.80
1 G
¥11,568.31

¥1,319.86

Available to ship on2025年4月24日Details

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25 MG
¥1,319.86
200 MG
¥3,601.49
500 MG
¥6,917.80
1 G
¥11,568.31

About This Item

Empirical Formula (Hill Notation):
C16H14F3N5O
CAS Number:
137234-62-9
Molecular Weight:
349.31
MDL number:
MFCD00905717
UNSPSC Code:
41116107
NACRES:
NA.24

¥1,319.86

Available to ship on2025年4月24日Details

Request a Bulk Order

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to Ph. Eur. Y0001395
traceable to USP 1718008

API family

voriconazole

CofA

current certificate can be downloaded

packaging

pkg of 1 g

application(s)

pharmaceutical

format

neat

storage temp.

2-8°C

SMILES string

C[C@@H](c1ncncc1F)[C@](O)(Cn2cncn2)c3ccc(F)cc3F

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700061P

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packaging

pkg of 1 × 1 g (700001P-1g), pkg of 1 × 25 mg (700001P-25mg), pkg of 1 × 200 mg (700001P-200mg), pkg of 1 × 500 mg (700001P-500mg)

packaging

pkg of 1 × 5 mg (700002P-5mg)

packaging

pkg of 1 × 25 mg (700054P-25mg), pkg of 1 × 5 mg (700054P-5mg)

packaging

pkg of 1 × 1 mg (700061P-1mg), pkg of 1 × 5 mg (700061P-5mg)

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

form

powder

form

powder

form

powder

form

powder

manufacturer/tradename

Avanti Polar Lipids 700001P

manufacturer/tradename

Avanti Polar Lipids

manufacturer/tradename

Avanti Polar Lipids

manufacturer/tradename

Avanti Polar Lipids

General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
Voriconazole is a synthetically prepared, broad-spectrum triazole derivative of fluconazole, which shows in vitro activity against many yeasts and a broad-spectrum of mold and dermatophyte isolates. Its mode of action involves the inhibition of cytochrome P450 (CYP)-dependent enzyme, 14-α-sterol demethylase, and hence it is involved in disrupting the cell membrane and terminate the fungal growth.[1]

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Voriconazole may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using high-performance liquid chromatography technique.[2]

Biochem/physiol Actions

Voriconazole is an antifungal used to treat serious fungal infections. Voriconazole inhibits ergosterol synthesis by inhibiting CYP450-dependent 14-α sterol demethylase resulting in a depletion of ergosterol in fungal cell membranes.
Voriconazole is an antifungal, which inhibits ergosterol synthesis.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC2092 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Chronic 3 - Carc. 2 - Muta. 2 - Repr. 2 - STOT RE 1 - STOT RE 2 Oral - STOT SE 2 Oral

Target Organs

Eyes, Liver,Kidney

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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    Development and validation of a stability-indicating HPLC method for determination of voriconazole and its related substances.
    Gu P and Li Y.
    Journal of Chromatographic Science, 47(7), 594-598 (2009)

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