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PHR1886

Supelco

Memantine Hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):
Memantine hydrochloride, 3,5-Dimethyl-1-adamantanamine hydrochloride, 3,5-Dimethylamantadine hydrochloride, 3,5-Dimethyltricyclo[3.3.1.13,7]decan-1-amine hydrochloride
Empirical Formula (Hill Notation):
C12H21N · HCl
CAS Number:
41100-52-1
Molecular Weight:
215.76
EC Number:
255-219-6
MDL number:
MFCD00214336
UNSPSC Code:
41116107
PubChem Substance ID:
329823633
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to USP 1380502

API family

memantine

CofA

current certificate can be downloaded

packaging

pkg of 1 g

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

Cl.C[C@]12CC3C[C@](C)(C1)CC(N)(C3)C2

InChI

1S/C12H21N.ClH/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10;/h9H,3-8,13H2,1-2H3;1H/t9-,10+,11-,12-;

InChI key

LDDHMLJTFXJGPI-VXMZOEJHSA-N

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Memantine Hydrochloride is a drug used for treating the Alzheimer′s disease by means of reducing abnormal activity in the brain. It can help patients suffering from dementia as it assists them to think more clearly and perform their chores with ease.

Application

Memantine Hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by spectrophotometry and gas chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB9158 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

related product

Product No.
Description
Pricing

1380524

Memantine Related Compound B, United States Pharmacopeia (USP) Reference Standard

1380535

Memantine Related Compound C, United States Pharmacopeia (USP) Reference Standard

1380502

Memantine hydrochloride, United States Pharmacopeia (USP) Reference Standard

1380513

Memantine Related Compound A, United States Pharmacopeia (USP) Reference Standard

1380546

Memantine Related Compound D, United States Pharmacopeia (USP) Reference Standard

1380557

Memantine Related Compound E, United States Pharmacopeia (USP) Reference Standard

1380580

Memantine Related Compound H, United States Pharmacopeia (USP) Reference Standard

1380579

Memantine Related Compound G, United States Pharmacopeia (USP) Reference Standard

1380591

Memantine Related Compound I, United States Pharmacopeia (USP) Reference Standard

PHR2450

Memantine Related Compound B, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2451

Memantine Related Compound C, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2449

Memantine Related Compound A, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2759

Memantine Related Compound F, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2761

Memantine Related Compound G, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2764

Memantine Related Compound H, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2765

Memantine Related Compound I, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2931

Memantine Related Compound E, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2583

Memantine Related Compound D, Pharmaceutical Secondary Standard; Certified Reference Material, certified reference material, pharmaceutical secondary standard, pkg of 100 mg

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Development and validation of stability-indicating GC-FID method for the quantitation of memantine hydrochloride and its nonchromophoric impurities in bulk and pharmaceutical dosages.
Jadhav SA, et al.
Chromatography Research International (2012)
Determination of memantine hydrochloride by spectrophotometry using anionic dyes, bromothymol blue and solochrome black T, in bulk and tablet dosage forms.
Rani AP, et al.
Chemical Science (2012)
Kazuoki Hirano et al.
Biochemical and biophysical research communications, 518(1), 161-170 (2019-08-23)
Chemical intervention of autophagy has been investigated in clinical trials for various age-related conditions such as sarcopenia and neurodegeneration. However, at present, no autophagy inducer has been established as a disease-modifying agent against neurodegenerative diseases. We screened a library consisting

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