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PHR1841

Supelco

Amoxapine

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Amoxapine, 2-Chloro-11-(1-piperazinyl)dibenz[b,f][1,4]oxazepine

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About This Item

Empirical Formula (Hill Notation):
C17H16ClN3O
CAS Number:
14028-44-5
Molecular Weight:
313.78
EC Number:
237-867-1
MDL number:
MFCD00069210
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to USP 1031401

API family

amoxapine

CofA

current certificate can be downloaded

packaging

pkg of 500 mg

application(s)

pharmaceutical

format

neat

storage temp.

2-30°C

SMILES string

Clc1ccc2Oc3ccccc3N=C(N4CCNCC4)c2c1

InChI

1S/C17H16ClN3O/c18-12-5-6-15-13(11-12)17(21-9-7-19-8-10-21)20-14-3-1-2-4-16(14)22-15/h1-6,11,19H,7-10H2

InChI key

QWGDMFLQWFTERH-UHFFFAOYSA-N

Gene Information

human ... DRD1(1812) , DRD2(1813) , DRD3(1814) , DRD4(1815) , DRD5(1816) , SLC6A2(6530) , SLC6A4(6532)

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General description

Amoxapine is a tricyclic antidepressant known to inhibit reuptake of neuronal transmitter. The drug helps in controlling agitation and anxiety along with depression.
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Amoxapine may be used as a pharmaceutical reference standard for the determination of the analyte in drug dosage forms by ultraviolet-spectrophotometric method.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB2753 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P301 + P312 + P330

Hazard Classifications

Acute Tox. 4 Oral

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
LRAD2912
LRAB2753

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DEVELOPMENT OF ULTRAVIOLET-SPECTROPHOTOMETRIC METHOD FOR ANALYSIS OF AMOXAPINE IN PHARMACEUTICAL DOSAGE FORM
Rangari, S et al.
Development, 11(3), 335-337 (2018)
Diagnostic pitfalls associated with amoxapine overdose: a case report
Miles MV, et al.
The American Journal of Emergency Medicine, 8(4), 335-337 (1990)

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