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COO/COA

PHR1799

Meloxicam

Name: Meloxicam
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Meloxicam, 4-Hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide

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About This Item

Empirical Formula (Hill Notation):

C₁₄H₁₃N₃O₄S₂

CAS Number:

71125-38-7

Molecular Weight:

351.40

UNSPSC Code:

41116107

NACRES:

NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to BP 629
traceable to Ph. Eur. Y0001080
traceable to USP 1379401

API family

meloxicam

CofA

current certificate can be downloaded

packaging

pkg of 500 mg

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

InChI

1S/C14H13N3O4S2/c1-8-7-15-14(22-8)16-13(19)11-12(18)9-5-3-4-6-10(9)23(20,21)17(11)2/h3-7,19H,1-2H3,(H,15,16)/b13-11+

InChI key

DWMREKMVXIFPFM-ACCUITESSA-N

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Related Categories

Analytical Reference Standards

Certified Reference Materials

Pharmacopeia & Metrological Institute Standards

General description

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Meloxicam is an oxicam derivative and belongs to the group of non-steroidal anti-inflammatory drugs (NSAID), used for its analgesic, anti-inflammatory, and antipyretic properties. It acts by inhibiting the activity of prostaglandin synthetase, thereby preventing the synthesis of prostaglandins and decreasing inflammation.

Application

This pharmaceutical secondary standard can also be used as follows:

Development of three spectrophotometric methods to determine meloxicam in its pharmaceutical formulations
Voltammetric determination of meloxicam in pharmaceutical formulations using a boron-doped diamond electrode (BDDE)
High-performance liquid chromatography-based quantitative analysis of meloxicam in its different tablet formulations
Development and validation of a reversed-phase HPLC method for the separation and estimation of meloxicam in its pharmaceutical dosage forms
Quantification of meloxicam and piroxicam from plasma samples using a liquid chromatography method combined with UV detection

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB7807 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

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Pricing

1379423

1379412

1379445

1379434

PHR2501

PHR2131

Meloxicam Impurity D

PHR2327

Meloxicam Impurity C, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2500

PHR2502

PHR2503

Meloxicam Impurity E, Pharmaceutical Secondary Standard; Certified Reference Material

Pictograms

GHS06

Signal Word

Danger

Hazard Statements

H301

Precautionary Statements

P264 - P270 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 3 Oral

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Reverse phase HPLC method development and validation for determination of Meloxicam in bulk and pharmaceutical formulation

Shaji J and Jain V

International Journal of Pharmaceutical Sciences and Research, 2, 107-107 (2011)

Electrochemical oxidation of anti-inflammatory drug meloxicam and its determination using boron doped diamond electrode

Selesovska R, et al.

Journal of Electroanalytical Chemistry, 858, 113758-113758 (2020)

High-performance liquid chromatography determination of meloxicam and piroxicam with ultraviolet detection

Cox S, et al.

Chromatography Research International, 2014 (2014)

Spectrophotometric estimation of meloxicam in bulk and its pharmaceutical formulations

Dhandapani B, et al.

International Journal of Pharma Sciences and Research, 1, 217-221 (2010)

Specific and simple hplc assay of ecofriendly meloxicam in pharmaceutical formulations

Mahmood KT, et al.

Journal of Pharmaceutical Sciences and Research, 2, 878-878 (2010)

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