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Chondroitin Sulfate Sodium

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):
Chondroitin sulfate sodium salt
CAS Number:
9082-07-9
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to BP 28
traceable to Ph. Eur. Y0000280
traceable to USP 1133570

API family

chondroitin sulfate

form

solid

CofA

current certificate can be downloaded

packaging

pkg of 500 mg

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

storage temp.

2-30°C

InChI

1S/C13H21NO15S/c1-2(15)14-3-8(7(19)13(28-11(3)22)29-30(23,24)25)26-12-6(18)4(16)5(17)9(27-12)10(20)21/h3-9,11-13,16-19,22H,1H3,(H,14,15)(H,20,21)(H,23,24,25)/t3-,4+,5+,6-,7-,8-,9+,11-,12-,13-/m1/s1

InChI key

KXKPYJOVDUMHGS-OSRGNVMNSA-N

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General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Chondroitin Sulfate Sodium is the sodium salt of the sulfated linear glycosaminoglycan obtained from bovine, porcine, or avian cartilages of healthy and domestic animals used for food by humans. It consists mostly of the sodium salt of the sulfate ester of N-acetylchondrosamine (2-acetamido-2-deoxy-β-d-galactopyranose) and D-glucuronic acid copolymer.

Application

Chondroitin Sulfate Sodium may be used as a pharmaceutical secondary reference standard for the determination of the analyte in pharmaceutical formulations by size-exclusion high-performance liquid chromatography(HPLC) method.
Chondroitin Sulfate Sodium may be used as a pharmaceutical secondary reference standard for the determination of the analyte in pharmaceutical formulations by size-exclusion and ion-pair high-performance liquid chromatography(HPLC) method.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC0285 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A size-exclusion HPLC method for the determination of sodium chondroitin sulfate in pharmaceutical preparations
Choi DW, et al.
Journal of Pharmaceutical and Biomedical Analysis, 31(6), 1229-1236 (2003)
Chondroitin Sulfate Sodium
Pharmacopeia, US
Journal of Pharmaceutical and Biomedical Analysis, 38(6), 4894-4894 (2020)
Simultaneous determination of chondroitin sulfate sodium, allantoin and pyridoxine hydrochloride in pharmaceutical eye drops by an ion-pair high-performance liquid chromatography
Jin P, et al.
Journal of Pharmaceutical and Biomedical Analysis, 50(3), 293-297 (2009)

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