PHR1784
Aripiprazole
Pharmaceutical Secondary Standard; Certified Reference Material
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Synonym(s):
Aripiprazole, 7-{4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butoxy}-3,4-dihydro-2(1H)-quinolinone
Empirical Formula (Hill Notation):
C23H27Cl2N3O2
Recommended Products
grade
certified reference material
pharmaceutical secondary standard
Quality Level
Agency
traceable to Ph. Eur. Y0001649
traceable to USP 1042634
API family
aripiprazole
CofA
current certificate can be downloaded
packaging
pkg of 500 mg
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-30°C
InChI
1S/C23H27Cl2N3O2/c24-19-4-3-5-21(23(19)25)28-13-11-27(12-14-28)10-1-2-15-30-18-8-6-17-7-9-22(29)26-20(17)16-18/h3-6,8,16H,1-2,7,9-15H2,(H,26,29)
InChI key
CEUORZQYGODEFX-UHFFFAOYSA-N
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General description
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Aripiprazole is a benzisoxazole derivative and second-generation antipsychotic and anti-depressant drug. It is used in the management of schizophrenia and bipolar I disorder. It shows partial agonistic activity towards dopamine D2 and serotonin 5-HT1A receptors and antagonistic activity at 5-HT2A receptors.
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Aripiprazole is a benzisoxazole derivative and second-generation antipsychotic and anti-depressant drug. It is used in the management of schizophrenia and bipolar I disorder. It shows partial agonistic activity towards dopamine D2 and serotonin 5-HT1A receptors and antagonistic activity at 5-HT2A receptors.
Application
This pharmaceutical secondary standard can also be used as follows:
- Development of a reversed phase-high-performance liquid chromatography (RP-HPLC) method for the determination of aripiprazole in the presence of nine of its impurities in both bulk and its pharmaceutical formulations
- Direct voltammetric determination of aripiprazole in pharmaceutical formulations, human serum, and urine samples
- Simultaneous estimation of aripiprazole and octoclothepin in pharmaceutical formulations and human urine samples by two different voltammetric methods using glassy carbon electrodes
- UV-spectroscopic determination of aripiprazole in pure and tablet formulations following ICH guidelines
- Multi-analysis of aripiprazole, clozapine, and sulpiride in pharmaceutical formulations and biological fluids by extraction-free UV-Visible spectrophotometric methods based on the ability of the three antipsychotic drugs to form stable ion-pair complexes with bromophenol blue (BPB) and bromothymol blue (BTB)
Analysis Note
These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.
Footnote
To see an example of a Certificate of Analysis for this material enter LRAC0259 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.
Recommended products
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
related product
Product No.
Description
Pricing
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Spectrophotometric determination of aripiprazole, clozapine and sulpiride by ion-pair extractionin in tablets and biological fluids
Eldidamony AM, et al.
International Journal of Pharmacy and Pharmaceutical Sciences, 7, 178-184 (2014)
Development and validation of UV spectrophotometric determination of aripiprazole in bulk and tablet formulation
Patle HS, et al.
International Journal of Current Pharmaceutical Research , 3, 59-61 (2011)
Electrochemistry and analytical determination of aripiprazole and octoclothepin at glassy carbon electrode
Merli D, et al.
Journal of Electroanalytical Chemistry, 711, 1-7 (2013)
Validation of an HPLC method for determination of aripiprazole and its impurities in pharmaceuticals
Djordjevic F, et al.
Acta Chromatographica , 1, 13-28 (2014)
Fabien Ducrocq et al.
Cell metabolism, 31(4), 755-772 (2020-03-07)
Reward-processing impairment is a common symptomatic dimension of several psychiatric disorders. However, whether the underlying pathological mechanisms are common is unknown. Herein, we asked if the decrease in the n-3 polyunsaturated fatty acid (PUFA) lipid species, consistently described in these
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