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PHR1751

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Guanfacine hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):
Guanfacine hydrochloride, N (Aminoiminomethyl)-2,6-dichlorobenzeneacetamide
Empirical Formula (Hill Notation):
C9H9Cl2N3O · HCl
CAS Number:
29110-48-3
Molecular Weight:
282.55
EC Number:
249-443-3
MDL number:
MFCD00798230
UNSPSC Code:
41116107
PubChem Substance ID:
329823595
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to USP 1302101

API family

guanfacine

CofA

current certificate can be downloaded

packaging

pkg of 500 mg

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

Cl.NC(=N)NC(=O)Cc1c(Cl)cccc1Cl

InChI

1S/C9H9Cl2N3O.ClH/c10-6-2-1-3-7(11)5(6)4-8(15)14-9(12)13;/h1-3H,4H2,(H4,12,13,14,15);1H

InChI key

DGFYECXYGUIODH-UHFFFAOYSA-N

Gene Information

human ... ADRA2A(150) , ADRA2B(151) , ADRA2C(152)

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General description

Guanfacine hydrochloride, is a selective α-adrenergic receptor agonist, that is used in the treatment of attention deficit hyperactivity disorder (ADHD) and hypertension.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Guanfacine hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in bulk drug and pharmaceutical formulations by spectrophotometry and high performance liquid chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

α-2 noradrenergic receptor agonist.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC3708 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

related product

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Pricing

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Spectrophotometric analysis of some guanidino drugs by acid-dye and charge-transfer complexation methods
Wahbi AM, et al.
Journal of Pharmaceutical and Biomedical Analysis, 11(8), 639- 645 (1993)
Guanfacine hydrochloride
USP42/NF37: United States Pharmacopeia and National Formulary
United States Pharmacopeia/National Formulary, 45(3), 2133-2133 (2018)
Guanfacine and secondary mania in children
Horrigan JP and Barnhill LJ
Journal of Affective Disorders, 54(3), 309- 314 (1999)

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