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PHR1730

Bupropion Hydrochloride

Name: Bupropion Hydrochloride
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Bupropion hydrochloride, (±)-2-(tert-Butyl amino)-1-(3-chlorophenyl)propan-1-one, (±)-1-(3-Chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanone hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₁₃H₁₈ClNO · HCl

CAS Number:

31677-93-7

Molecular Weight:

276.20

EC Number:

250-759-9

MDL number:

MFCD00055209

UNSPSC Code:

41116107

PubChem Substance ID:

329823579

NACRES:

NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to USP 1078733

API family

bupropion

CofA

current certificate can be downloaded

packaging

pkg of 1 g

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

Cl[H].CC(NC(C)(C)C)C(=O)c1cccc(Cl)c1

InChI

1S/C13H18ClNO.ClH/c1-9(15-13(2,3)4)12(16)10-6-5-7-11(14)8-10;/h5-9,15H,1-4H3;1H

InChI key

HEYVINCGKDONRU-UHFFFAOYSA-N

Gene Information

human ... SLC6A2(6530) , SLC6A3(6531)

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Related Categories

Analytical Reference Standards

Certified Reference Materials

Pharmacopeia & Metrological Institute Standards

General description

Bupropion Hydrochloride is an aminoketone derivative and an antidepressant drug, widely used to treat depression. It is also employed for the treatment of obesity, smoking cessation and attention deficit hyperactivity disorder.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Bupropion Hydrochloride may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using spectrophotometric technique and electroanalytical technique.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC3044 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

related product

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Description

Pricing

PHR1755

PHR1754

1078857

1117020

Chloropropiophenone, United States Pharmacopeia (USP) Reference Standard

PHR3178

Bupropion Hydrobromide, pharmaceutical secondary standard, certified reference material

Pictograms

GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P301 + P312 + P330

Hazard Classifications

Acute Tox. 4 Oral

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

LRAD2985

LRAA7912

LRAC3044

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HPLC assay for bupropion and its major metabolites in human plasma.

Loboz K K, et al.

Journal of Chromatography. B, Biomedical Sciences and Applications, 823(2), 115-121 (2005)

The determination of bupropion hydrochloride in pharmaceutical dosage forms by original UV and second derivative UV spectrophotometry, potentiometric and conductometric methods

Yeniceli D and Dogrukal AKD

Turkish Journal of Pharmaceutical Sciences, 7, 99-110 (2010)

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