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PHR1717

Supelco

Methylprednisolone

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

6α-Methylprednisolone, 11β,17α,21-Trihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione, 6α-Methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione, Medrol, Medrone

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About This Item

Empirical Formula (Hill Notation):
C22H30O5
CAS Number:
83-43-2
Molecular Weight:
374.47
Beilstein:
2340300
EC Number:
201-476-4
MDL number:
MFCD00010591
UNSPSC Code:
41116107
PubChem Substance ID:
329823571
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to BP 248
traceable to Ph. Eur. M1750000
traceable to USP 1435003

API family

methylprednisolone

CofA

current certificate can be downloaded

packaging

pkg of 500 mg

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

[H][C@@]12C[C@H](C)C3=CC(=O)C=C[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO

InChI

1S/C22H30O5/c1-12-8-14-15-5-7-22(27,18(26)11-23)21(15,3)10-17(25)19(14)20(2)6-4-13(24)9-16(12)20/h4,6,9,12,14-15,17,19,23,25,27H,5,7-8,10-11H2,1-3H3/t12-,14-,15-,17-,19+,20-,21-,22-/m0/s1

InChI key

VHRSUDSXCMQTMA-PJHHCJLFSA-N

Gene Information

human ... NR3C1(2908)

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Methylprednisolone is a synthetic corticosteroid drug which is employed for the management of inflammatory diseases. It is used to relieve the inflammations caused by psoriasis, eczema, arthritis, asthma and rhinitis. It is also widely employed for the treatment of acute lung injury caused by acid aspiration.

Application

Methylprednisolone may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and counterfeit cosmetic products by chromatography and electroanalytical techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB8710 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

related product

Product No.
Description
Pricing

1435003

Methylprednisolone, United States Pharmacopeia (USP) Reference Standard

1437009

Methylprednisolone hemisuccinate, United States Pharmacopeia (USP) Reference Standard

M1750000

Methylprednisolone, European Pharmacopoeia (EP) Reference Standard

M1755200

Methylprednisolone hydrogen succinate, European Pharmacopoeia (EP) Reference Standard

M1755220

Methylprednisolone hydrogen succinate for performance test, European Pharmacopoeia (EP) Reference Standard

M1755000

Methylprednisolone acetate, European Pharmacopoeia (EP) Reference Standard

1436006

Methylprednisolone acetate, United States Pharmacopeia (USP) Reference Standard

PHR1718

Methylprednisolone Acetate, Pharmaceutical Secondary Standard; Certified Reference Material

Y0001759

Methylprednisolone hydrogen succinate for peak identification, European Pharmacopoeia (EP) Reference Standard

Y0001736

Methylprednisolone acetate for peak identification, European Pharmacopoeia (EP) Reference Standard

Y0001760

Methylprednisolone acetate for system suitability, European Pharmacopoeia (EP) Reference Standard

Y0001799

Methylprednisolone for system suitability A, European Pharmacopoeia (EP) Reference Standard

1435036

Methylprednisolone Related Compound C, United States Pharmacopeia (USP) Reference Standard

1435014

Methylprednisolone Related Compound A, United States Pharmacopeia (USP) Reference Standard

BP248

Methylprednisolone, British Pharmacopoeia (BP) Reference Standard

BP249

Methylprednisolone acetate, British Pharmacopoeia (BP) Reference Standard

BP572

Deltamedrane, British Pharmacopoeia (BP) Reference Standard

1437042

Methyl Prednisolone Hemisuccinate Related Compound D, United States Pharmacopeia (USP) Reference Standard

1437020

Methylprednisolone Hemisuccinate Related Compound B, United States Pharmacopeia (USP) Reference Standard

PHR3043

Methylprednisolone Related Compound C, pharmaceutical secondary standard, certified reference material

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H360FD,H373

Hazard Classifications

Repr. 1B - STOT RE 2

Target Organs

Adrenal gland,Immune system

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

监管及禁止进口产品

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
LRAD4756
LRAC4830
LRAB8710
LRAA7305

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If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

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Differential pulse voltammetric determination of methylprednisolone in pharmaceuticals and human biological fluids
Goyal RN, et al.
Analytica Chimica Acta, 605(1), 34-40 (2007)
Methylprednisolone
USP42-NF37
United States Pharmacopeia/National Formulary, 44(3), 2859-2859 (2013)
Simultaneous determination of cortisol, dexamethasone, methylprednisolone, prednisone, prednisolone, mycophenolic acid and mycophenolic acid glucuronide in human plasma utilizing liquid chromatography-tandem mass spectrometry
DiFrancesco R, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 859(1), 42-51 (2007)
LC-MS method for the simultaneous determination of six glucocorticoids in pharmaceutical formulations and counterfeit cosmetic products
Fiori J and Andrisano V
Journal of Pharmaceutical and Biomedical Analysis, 91, 185-192 (2014)
Determination of methylprednisolone acetate in biological fluids at gold nanoparticles modified ITO electrode
Goyal RN, et al.
Journal of Pharmaceutical and Biomedical Analysis, 44(5), 1147-1153 (2007)

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