Skip to Content
Merck
CN
All Photos(1)

Documents

Safety Information

PHR1691

Supelco

4-Epianhydrotetracycline hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

Sign Into View Organizational & Contract Pricing
All Photos(1)
Synonym(s):
4-Epianhydrotetracycline hydrochloride, (4R,4aS,12aS)-4-(Dimethylamino)-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-2-naphthacenecarboxamide monohydrochloride
Empirical Formula (Hill Notation):
C22H22N2O7 · HCl
CAS Number:
4465-65-0
Molecular Weight:
462.88
Beilstein:
3840711
MDL number:
MFCD00151455
UNSPSC Code:
41116107
PubChem Substance ID:
329823559
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to Ph. Eur. E0400000
traceable to USP 1236506

API family

chlortetracycline, tetracycline

CofA

current certificate can be downloaded

packaging

pkg of 500 mg

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

Cl[H].[H][C@@]12Cc3c(C)c4cccc(O)c4c(O)c3C(=O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@@H]2N(C)C

InChI

1S/C22H22N2O7.ClH/c1-8-9-5-4-6-12(25)13(9)17(26)14-10(8)7-11-16(24(2)3)18(27)15(21(23)30)20(29)22(11,31)19(14)28;/h4-6,11,16,25-27,31H,7H2,1-3H3,(H2,23,30);1H/t11-,16+,22-;/m0./s1

InChI key

XBSQEFHDCDFNJU-MOMXNFOMSA-N

Looking for similar products? Visit Product Comparison Guide

Related Categories

General description

4-Epianhydrotetracycline hydrochloride is a degradation product of tetracyclines which are used as veterinary medicines.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

4-Epianhydrotetracycline hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in commercial bulk and pharmaceutical products by high performance liquid chromatography (HPLC).
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA6863 in the slot below. This is an example certificate only and may not be the lot that you receive.

related product

Product No.
Description
Pricing

PHR1041

Tetracycline hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

1236506

4-Epianhydrotetracycline hydrochloride, United States Pharmacopeia (USP) Reference Standard

A1200000

Anhydrotetracycline hydrochloride, European Pharmacopoeia (EP) Reference Standard

C2000000

Chlortetracycline hydrochloride, European Pharmacopoeia (EP) Reference Standard

E0400000

4-Epianhydrotetracycline hydrochloride, European Pharmacopoeia (EP) Reference Standard

E0600000

4-Epitetracycline hydrochloride, European Pharmacopoeia (EP) Reference Standard

T0600000

Tetracycline hydrochloride, European Pharmacopoeia (EP) Reference Standard

Y0001451

Chlortetracycline for system suitability, European Pharmacopoeia (EP) Reference Standard

1651009

Tetracycline hydrochloride, United States Pharmacopeia (USP) Reference Standard

PHR1520

Chlortetracycline Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

1129007

Chlortetracycline hydrochloride, United States Pharmacopeia (USP) Reference Standard

1237509

Epitetracycline hydrochloride, United States Pharmacopeia (USP) Reference Standard

1035708

Anhydrotetracycline hydrochloride, United States Pharmacopeia (USP) Reference Standard

BP783

Chlortetracycline hydrochloride, British Pharmacopoeia (BP) Reference Standard

BP480

Tetracycline hydrochloride, British Pharmacopoeia (BP) Reference Standard

PHR3175

Anhydrotetracycline Hydrochloride, pharmaceutical secondary standard, certified reference material

WGK

WGK 3

Regulatory Information

监管及禁止进口产品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

4-Epianhydrotetracycline
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia/National Formulary, 6636-6636 (2013)
A high performance liquid chromatographic system for the analysis of tetracycline drug standards, analogs, degradation products and other impurities
Mack GD and Ashworth RB
Journal of Chromatographic Science, 16(3), 93-101 (1978)
Emad M Hussien
Biomedical chromatography : BMC, 28(9), 1278-1283 (2014-03-13)
A novel reversed-phase HPLC method was developed and validated for the assay of tetracycline hydrochloride and the limit of 4-epianhydrotetracycline hydrochloride impurity in tetracycline hydrochloride commercial bulk and pharmaceutical products. The method employed L1 (3 µm, 150 × 4.6 mm) columns, a mobile phase

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service