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PHR1677

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Anthralin (Dithranol)

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):
Dithranol, 1,8,9-Anthracenetriol, 1,8-Dihydroxy-9(10H)-anthracenone, 1,8-Dihydroxyanthrone, Anthralin
Empirical Formula (Hill Notation):
C14H10O3
CAS Number:
1143-38-0
Molecular Weight:
226.23
Beilstein:
2054360
EC Number:
214-538-0
MDL number:
MFCD00053409
UNSPSC Code:
41116107
PubChem Substance ID:
329823549
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to Ph. Eur. D2953000
traceable to USP 1039006

API family

anthralin, dithranol

CofA

current certificate can be downloaded

packaging

pkg of 1 g

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

178-181 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

Oc1cccc2Cc3cccc(O)c3C(=O)c12

InChI

1S/C14H10O3/c15-10-5-1-3-8-7-9-4-2-6-11(16)13(9)14(17)12(8)10/h1-6,15-16H,7H2

InChI key

NUZWLKWWNNJHPT-UHFFFAOYSA-N

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General description

Anthralin (Dithranol) is the synthetic form of chrysarobin. It is widely used as a medication for the human skin affected with psoriasis and in short contact therapy to minimize the staining, irritation, etc.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Anthralin (Dithranol) may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using high pressure liquid chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA6122 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Psoriasis and Psoriatic Arthritis: An Integrated Approach, 70(11), 1205-1207 (2005)
High-pressure liquid chromatographic determination of anthralin in ointments
Caron C-J, et al.
Journal of Pharmaceutical Sciences, 70(11), 1205-1207 (1981)

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