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PHR1664

Supelco

Rifamycin Sodium

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Rifamycin SV sodium salt

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About This Item

Empirical Formula (Hill Notation):
C37H46NNaO12
CAS Number:
14897-39-3
Molecular Weight:
719.75
EC Number:
238-965-7
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to Ph. Eur. R1000000

API family

rifampicin, rifamycin

CofA

current certificate can be downloaded

packaging

pkg of 500 mg

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

-10 to -25°C

SMILES string

[Na+].CO[C@H]1\C=C\O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(NC(=O)C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)cc([O-])c4c3C2=O

InChI

1S/C37H47NO12.Na/c1-16-11-10-12-17(2)36(46)38-23-15-24(40)26-27(32(23)44)31(43)21(6)34-28(26)35(45)37(8,50-34)48-14-13-25(47-9)18(3)33(49-22(7)39)20(5)30(42)19(4)29(16)41;/h10-16,18-20,25,29-30,33,40-44H,1-9H3,(H,38,46);/q;+1/p-1/b11-10+,14-13+,17-12-;/t16-,18+,19+,20+,25-,29-,30+,33+,37-;/m0./s1

InChI key

YVOFSHPIJOYKSH-NLYBMVFSSA-M

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Rifamycin Sodium is a simplest rifamycin obtained via the elimination of glycolic moity from rifamycin B. It belongs to the ansamicin group of antibiotics. Rifamycin sodium is widely used in surgery and for the treatment of synovitis by intracellular injections.

Application

Rifamycin Sodium may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using manual and semiautomatic kinetic method.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA6000 in the slot below. This is an example certificate only and may not be the lot that you receive.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

监管及禁止进口产品

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
LRAD9759
LRAC7558
LRAC1636
LRAA6000

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Kinetic determination of ansamicins in pharmaceutical formulations and human urine. Manual and semiautomatic (stopped-flow) procedures
Espinosa-Mansilla A, et al.
Analytica Chimica Acta, 376(3), 365-375 (1998)
Antibiotic and chemotherapy e-book (2010)

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