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PHR1656

Cetirizine Hydrochloride

Name: Cetirizine Hydrochloride
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Cetirizine dihydrochloride, 2-[4-(4-Chlorobenzhydryl) piperazine-1-yl]ethoxyacetic acid dihydrochloride, CE, CET, CTZ, [2-[4-[(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetic acid dihydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₂₁H₂₅ClN₂O₃ · 2HCl

CAS Number:

83881-52-1

Molecular Weight:

461.81

MDL number:

MFCD00941428

UNSPSC Code:

41116107

PubChem Substance ID:

329823534

NACRES:

NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to BP 837
traceable to Ph. Eur. C0980650
traceable to USP 1102929

API family

cetirizine

CofA

current certificate can be downloaded

packaging

pkg of 1 g

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

OC(COCCN1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=CC=C3)CC1)=O.[H]Cl.[H]Cl

InChI

1S/C21H25ClN2O3.2ClH/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26;;/h1-9,21H,10-16H2,(H,25,26);2*1H

InChI key

PGLIUCLTXOYQMV-UHFFFAOYSA-N

Gene Information

human ... HRH1(3269)

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Related Categories

Analytical Reference Standards

Certified Reference Materials

Pharmacopeia & Metrological Institute Standards

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Cetirizine hydrochloride, a second generation antihistaminic drug, is one of the carboxylated metabolites of hydroxyzine that can typically bind to histamine H₁ receptor. It is effective against diseases such as urticaria, angioedema, allergies and hay fever.

Application

Cetirizine Hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Cetirizine hydrochloride is an orally active and selective H1-receptor antagonist. Antihistaminic; Piperazines. Non-sedating type histamine H1-receptor antagonist; major metabolite of hydroxyzine. Pharmacological activity resides primarily in the (R)-isomer.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA5757 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

related product

Product No.

Description

Pricing

1102930

1112467

4-Chlorobenzophenone, United States Pharmacopeia (USP) Reference Standard

1102952

1102941

PHR1710

Cetirizine hydrochloride Related Compound A, Pharmaceutical Secondary Standard; Certified Reference Material

1102963

BP837

Cetirizine hydrochloride, British Pharmacopoeia (BP) Reference Standard

BP1081

Cetirizine impurity standard, British Pharmacopoeia (BP) Reference Standard

BP441

1,4-Bis(4-chlorobenzhydryl)piperazine, British Pharmacopoeia (BP) Reference Standard

PHR2620

4-Chlorobenzophenone, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2852

PHR3195

Levocetirizine Dihydrochloride, pharmaceutical secondary standard, certified reference material

Pictograms

GHS07

Signal Word

Warning

Hazard Statements

H302

Hazard Classifications

Acute Tox. 4 Oral

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Determination and quantification of cetirizine HCl in dosage formulations by RP-HPLC.

ARAYNE MS, et al.

Science, 1(4), 1-4 (2005)

Development and validation of stability indicating assay method of cetirizine hydrochloride by HPLC.

Khan MI, et al.

African Journal of Pharmacy and Pharmacology, 5(2), 143-149 (2011)

A rapid, stability indicating RP-UPLC method for simultaneous determination of ambroxol hydrochloride, cetirizine hydrochloride and antimicrobial preservatives in liquid pharmaceutical formulation.

Trivedi RK, et al.

Scientia Pharmaceutica, 79(3), 525-544 (2011)

Development and validation of a novel RP-HPLC method for simultaneous determination of paracetamol, phenylephrine hydrochloride, caffeine, cetirizine and nimesulide in tablet formulation.

Dewani AP, et al.

Arabian Journal of Chemistry, 8(4), 591-598 (2015)

RP-HPLC and spectrophotometric estimation of ambroxol hydrochloride and cetirizine hydrochloride in combined dosage form.

Bhatia NM, et al.

Indian Journal of Pharmaceutical Sciences, 70(5), 603-603 (2008)

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