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PHR1638

Supelco

Alfuzosin hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):
N-(3-((4-Amino-6,7-dimethoxy-2-quinazolinyl)methylamino)propyl)tetrahydro-2-furancarboxamide hydrochloride, Uroxatral hydrochloride
Empirical Formula (Hill Notation):
C19H27N5O4 · HCl
CAS Number:
81403-68-1
Molecular Weight:
425.91
MDL number:
MFCD00879135
UNSPSC Code:
41116107
PubChem Substance ID:
329823527
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to Ph. Eur. A0325800
traceable to USP 1012917

API family

alfuzosin

CofA

current certificate can be downloaded

packaging

ampule of 1 × 1 g

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

Cl.COc1cc2nc(nc(N)c2cc1OC)N(C)CCCNC(=O)C3CCCO3

InChI

1S/C19H27N5O4.ClH/c1-24(8-5-7-21-18(25)14-6-4-9-28-14)19-22-13-11-16(27-3)15(26-2)10-12(13)17(20)23-19;/h10-11,14H,4-9H2,1-3H3,(H,21,25)(H2,20,22,23);1H

InChI key

YTNKWDJILNVLGX-UHFFFAOYSA-N

Gene Information

human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146)

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Alfuzosin hydrochloride may be used as a pharmaceutical reference standard for the quantification of alfuzosin hydrochloride levels in pharmaceutical formulations by reverse phase high-performance liquid chromatography (RP-HPLC), high performance thin layer chromatography (HPTLC) and spectrophotometry.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Alfuzosin hydrochloride is an alpha-adrenergic blocker used to treat benign prostatic hyperplasia (BPH). It works by relaxing the muscles in the prostate and bladder neck, making it easier to urinate.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA5304 in the slot below. This is an example certificate only and may not be the lot that you receive.

related product

Product No.
Description
Pricing

1012917

Alfuzosin hydrochloride, United States Pharmacopeia (USP) Reference Standard

A0325800

Alfuzosin hydrochloride, European Pharmacopoeia (EP) Reference Standard

Y0000832

Alfuzosin for system suitability, European Pharmacopoeia (EP) Reference Standard

1012871

Alfuzosin System Suitability Mixture A, United States Pharmacopeia (USP) Reference Standard

1012928

Alfuzosin System Suitability Mixture, United States Pharmacopeia (USP) Reference Standard

Y0001906

Alfuzosin for system suitability A, European Pharmacopoeia (EP) Reference Standard

Y0001883

Alfuzosin for peak identification, European Pharmacopoeia (EP) Reference Standard

BP825

Alfuzosin hydrochloride, British Pharmacopoeia (BP) Reference Standard

BP847

Alfuzosin impurity standard, British Pharmacopoeia (BP) Reference Standard

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Spectrophotometric determination of alfuzosin HCl in pharmaceutical formulations with some sulphonephthalein dyes
Ashour S, et al.
International Journal of Biomedical Science : IJBS, 2(3), 273-278 (2006)
Development of new spectrophotometric methods for the determination of Alfuzosin hydrochloride in bulk and pharmaceutical formulations
Kumar DR, et al.
Orient. J. Chem., 24(2), 725-728 (2008)
Validated HPLC and HPTLC stability-indicating methods for determination of alfuzosin hydrochloride in bulk powder and pharmaceutical formulations
Salah FA, et al.
Journal of Separation Science, 29(18), 2716-2724 (2006)
Development and validation of reverse phase high performance liquid chromatography and high performance thin layer chromatography methods for estimation of alfuzosin hydrochloride in bulk and in pharmaceutical formulations
Patel DB and Patel NJ
International Journal of ChemTech Research, 1(4), 985-990 (2009)

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