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PHR1606

Supelco

Hydrocortisone Acetate

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Hydrocortisone 21-acetate, 11β,17α,21-Trihydroxy-4-pregnene-3,20-dione 21-acetate, 17-α-Hydroxycorticosterone acetate, 17-Hydroxycorticosterone 21-acetate, 21-Acetoxy-4-pregnene-11β,17α-diol-3,20-dione, 4-Pregnene-11β,17α,21-triol-3,20-dione 21-acetate

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About This Item

Empirical Formula (Hill Notation):
C23H32O6
CAS Number:
50-03-3
Molecular Weight:
404.50
Beilstein:
2066841
EC Number:
200-004-4
MDL number:
MFCD00037714
UNSPSC Code:
41116107
PubChem Substance ID:
329823503
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to BP 584
traceable to Ph. Eur. H1400000
traceable to USP 1317007

API family

hydrocortisone

CofA

current certificate can be downloaded

packaging

pkg of 1 g

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

223 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)COC(C)=O

InChI

1S/C23H32O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h10,16-18,20,26,28H,4-9,11-12H2,1-3H3/t16-,17-,18-,20+,21-,22-,23-/m0/s1

InChI key

ALEXXDVDDISNDU-JZYPGELDSA-N

Gene Information

human ... NR3C1(2908)

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Hydrocortisone Acetate belongs to the class of corticosteroids, exhibiting antipruritic, anti-inflammatory and vasoconstrictive properties. It is used in the treatment of various conditions such as allergic and breathing disorders or skin conditions.

Application

Hydrocortisone Acetate may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using reversed-phase high-performance liquid chromatography and thin layer chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC3177 in the slot below. This is an example certificate only and may not be the lot that you receive.

related product

Product No.
Description
Pricing

PHR1014

Hydrocortisone, Pharmaceutical Secondary Standard; Certified Reference Material

1316004

Hydrocortisone, United States Pharmacopeia (USP) Reference Standard

1317302

Hydrocortisone butyrate, United States Pharmacopeia (USP) Reference Standard

1319002

Hydrocortisone hemisuccinate, United States Pharmacopeia (USP) Reference Standard

H1400000

Hydrocortisone acetate, European Pharmacopoeia (EP) Reference Standard

H1300000

Hydrocortisone, European Pharmacopoeia (EP) Reference Standard

H1425000

Hydrocortisone hydrogen succinate, European Pharmacopoeia (EP) Reference Standard

Y0001092

Hydrocortisone for peak identification, European Pharmacopoeia (EP) Reference Standard

Y0001482

Hydrocortisone acetate for peak identification, European Pharmacopoeia (EP) Reference Standard

1321004

Hydrocortisone valerate, United States Pharmacopeia (USP) Reference Standard

1320001

Hydrocortisone phosphate triethylamine, United States Pharmacopeia (USP) Reference Standard

BP576

Hydrocortisone, British Pharmacopoeia (BP) Assay Standard

BP584

Hydrocortisone acetate, British Pharmacopoeia (BP) Reference Standard

BP187

Hydrocortisone hydrogen succinate, British Pharmacopoeia (BP) Reference Standard

PHR1926

Hydrocortisone Hemisuccinate, Pharmaceutical Secondary Standard; Certified Reference Material

BP188

Hydrocortisone sodium phosphate, British Pharmacopoeia (BP) Reference Standard

PHR2160

Hydrocortisone Impurity J, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2157

Hydrocortisone Impurity E, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2162

Hydrocortisone Impurity L, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2161

Hydrocortisone Impurity K, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2159

Hydrocortisone Impurity G, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2163

Hydrocortisone Impurity M, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2158

Hydrocortisone Impurity F, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2164

6a-Hydroxyhydrocortisone, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2156

Hydrocortisone Impurity D, Pharmaceutical Secondary Standard; Certified Reference Material

PHR3185

Hydrocortisone Valerate, pharmaceutical secondary standard, certified reference material

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H360Df,H373

Hazard Classifications

Repr. 1B - STOT RE 2

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

监管及禁止进口产品

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
LRAD6984
LRAD3708
LRAD3273
LRAC3177
LRAB3722

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If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

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Simultaneous determination of methylparaben, propylparaben, hydrocortisone acetate and its degradation products in a topical cream by RP-HPLC
Hajkova R, et al.
Journal of Pharmaceutical and Biomedical Analysis, 32(4), 921-927 (2003)
Validation of a thin-layer chromatography for the determination of hydrocortisone acetate and lidocaine in a pharmaceutical preparation
Dolowry M, et al.
TheScientificWorldJournal, 32(4), 921-927 (2014)
Simultaneous determination of methylparaben, propylparaben, hydrocortisone acetate and its degradation products in a topical cream by RP-HPLC.
Hajkova R, et al.
Journal of Pharmaceutical and Biomedical Analysis, 32(4-5), 921-927 (2003)

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