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PHR1582

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Dehydroacetic acid

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):
Dehydroacetic acid, 2-Acetyl-5-hydroxy-3-oxo-4-hexenoic acid δ-lactone
Empirical Formula (Hill Notation):
C8H8O4
CAS Number:
520-45-6
Molecular Weight:
168.15
Beilstein:
6129
EC Number:
208-293-9
MDL number:
MFCD00066709
UNSPSC Code:
41116107
PubChem Substance ID:
329823490
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to USP 1166309

API family

dehydroacetic acid

CofA

current certificate can be downloaded

packaging

pkg of 1 g

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

bp

270 °C (lit.)

mp

111-113 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

CC(=O)C1C(=O)OC(C)=CC1=O

InChI

1S/C8H8O4/c1-4-3-6(10)7(5(2)9)8(11)12-4/h3,7H,1-2H3

InChI key

PGRHXDWITVMQBC-UHFFFAOYSA-N

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General description

Dehydroacetic acid is a pyrone derivative, that is typically synthesized by the base-catalyzed dimerization of diketene. It is used as a preservative in pharmaceutical, food and cosmetic products.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Dehydroacetic acid may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical, food and cosmetic formulations by chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA4498 in the slot below. This is an example certificate only and may not be the lot that you receive.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

WGK

WGK 1

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Simultaneous determination of nine kinds of preservatives in foods by HPLC
Kishi H and Yamada T
Journal of Food Hygiene and Safety, 48(3), 58-63 (2007)
Dehydroacetic acid, triacetic acid lactone, and related pyrones
Advances in Heterocyclic Chemistry, 53, 1-84 (1992)
Simultaneous determination of sorbic acid, dehydroacetic acid and benzoic acid by gas chromatography-mass spectrometry
Kakemoto M
Journal of Chromatography A, 594(1-2), 253-257 (1992)
Comparing micellar electrokinetic chromatography and microemulsion electrokinetic chromatography for the analysis of preservatives in pharmaceutical and cosmetic products
Huang HY, et al.
Journal of Chromatography A, 993(1-2), 153-164 (2003)
E Mikami et al.
Journal of pharmaceutical and biomedical analysis, 28(2), 261-267 (2002-04-04)
A high-performance liquid chromatographic (HPLC) method for simultaneous determination of dehydroacetic acid (DHA), benzoic acid (BA), sorbic acid (SOA) and salicylic acid (SA) was developed for application to cosmetic products. Isocratic reversed-phase HPLC was employed for quantitative analysis using tetra-n-butylammonium

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