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PHR1578

Supelco

Trolamine

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Triethanolamine, 2,2′,2′′-Nitrilotriethanol, Tris(2-hydroxyethyl)amine

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About This Item

Linear Formula:
(HOCH2CH2)3N
CAS Number:
102-71-6
Molecular Weight:
149.19
Beilstein:
1699263
EC Number:
203-049-8
MDL number:
MFCD00002855
UNSPSC Code:
41116107
PubChem Substance ID:
329823486
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to Ph. Eur. T2545000
traceable to USP 1696958

vapor density

5.14 (vs air)

vapor pressure

0.01 mmHg ( 20 °C)

API family

trolamine

CofA

current certificate can be downloaded

autoignition temp.

600 °F

expl. lim.

8.5 %

packaging

ampule of 5 mL

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

refractive index

n20/D 1.485 (lit.)

useful pH range

7.3-8.3

pKa (25 °C)

7.8

bp

190-193 °C/5 mmHg (lit.)

mp

17.9-21 °C (lit.)

density

1.124 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

OCCN(CCO)CCO

InChI

1S/C6H15NO3/c8-4-1-7(2-5-9)3-6-10/h8-10H,1-6H2

InChI key

GSEJCLTVZPLZKY-UHFFFAOYSA-N

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General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standard. Trolamine belongs to the family of ethanolamines, offering a broad spectrum of applications due to its ability to combine the properties of both amines and alcohols. Its property as an organic base to form soluble neutralization products with insoluble acids is reported.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC2885 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

WGK

WGK 1

Flash Point(F)

354.2 °F

Flash Point(C)

179 °C

Regulatory Information

监管及禁止进口产品

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
LRAD6775
LRAD4790
LRAC2885
LRAD3268
LRAB7666

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If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

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Find documentation for the products that you have recently purchased in the Document Library.

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Toxicology of Mono-, Di-, and Triethanolamine
Knaak BJ, et al.
Reviews of Environmental Contamination and Toxicology, 1-86 (1997)
The Preparation of Emulsions and Other Products with Triethanolamine N(C2H4OH)3, 1-86 (1933)

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